CAJ | 학술논문

目的探讨B细胞幼淋巴细胞白血病(B-PLL)临床特征.方法报道1例33岁男性B-PLL患者的临床表现和治疗经过.结果患者血小板减少、淋巴细胞增高,有全身B症状、伴随脾大和淋巴结肿大.患者拒绝异基因造血干细胞移植,予氟达拉滨、环磷酰胺联合利妥昔单抗组成的RFC方案化疗后,患者达到血液、骨髓、免疫表型完全缓解.结论 RFC方案可能是B-PLL合适且有效的初始治疗选择之一.
목적 탐토B세포유림파세포백혈병(B-PLL)림상특정.방법 보도1례33세남성B-PLL환자적림상표현화치료경과.결과 환자혈소판감소、림파세포증고,유전신B증상、반수비대화림파결종대.환자거절이기인조혈간세포이식,여불체랍빈、배린선알연합리타석단항조성적RFC방안화료후,환자체도혈액、골수、면역표형완전완해.결론 RFC방안가능시B-PLL합괄차유효적초시치료선택지일.
Objective To explore the clinical characteristics of B cell prolymphocytic leukemia (B-PLL).Methods The clinical manifestation,treatment and outcome of a 33-year-old man with B-PLL were reported.Results The young patient had thrombocytopenia and systemic B-symptoms,markedly raised lymphocyte'count,bulky splenomegaly and lymphadenopathy.He refused stem cell transplant,so RFC regimen (fludarabine,cyclophosphomide and rituximab) therapy were administered.After 4 cycles of RFC therapy,the patient achieved a complete immunophenotypical and hematological remission response.Conclusion RFC therapy might be a feasible and useful treatment option for B-PLL.