中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
11期
1486-1489
,共4页
段智%陈辉%汪砥%许奇美%韦妹艳
段智%陳輝%汪砥%許奇美%韋妹豔
단지%진휘%왕지%허기미%위매염
受体,表皮生长因子/分析%蛋白激酶类/分析%胃肿瘤/病理学
受體,錶皮生長因子/分析%蛋白激酶類/分析%胃腫瘤/病理學
수체,표피생장인자/분석%단백격매류/분석%위종류/병이학
Receptor,epidermal growth factor/analysis%Protein kinases/analysis%Stomach neoplasms/pathology
目的 探讨胃癌组织中表皮生长因子受体(EGFR)和蛋白激酶(AKT)表达情况与胃癌的临床病理特征相关性.方法 用免疫组化的方法分别检测153例胃癌患者的癌组织和癌旁正常胃组织中EGFR、AKT的表达程度,分析其与患者临床病理特征的相关性.结果 在不同的性别、年龄及不同肿瘤病理类型、分化程度的患者中,胃癌组织EGFR、AKT的表达程度比较差异无统计学意义(P＞0.05).EGFR水平与TNM分期有关(x2=5.43,P＜0.05)；AKT的表达水平与肿瘤大小,T分期,TNM分期有关(x2=4.73、4.95、5.32,P＜0.05或P＜0.01)；出现淋巴结转移及远处转移的胃癌组织中AKT(x2 =4.83、4.75,P＜0.05)、EGFR(x2=4.67,4.58,P＜0.05)表达水平分别较无转移者高.结论 检测胃癌组织中EGFR、AKT的表达对于胃癌的诊断、疾病的分期和转移的判断有一定的参考意义.
目的 探討胃癌組織中錶皮生長因子受體(EGFR)和蛋白激酶(AKT)錶達情況與胃癌的臨床病理特徵相關性.方法 用免疫組化的方法分彆檢測153例胃癌患者的癌組織和癌徬正常胃組織中EGFR、AKT的錶達程度,分析其與患者臨床病理特徵的相關性.結果 在不同的性彆、年齡及不同腫瘤病理類型、分化程度的患者中,胃癌組織EGFR、AKT的錶達程度比較差異無統計學意義(P＞0.05).EGFR水平與TNM分期有關(x2=5.43,P＜0.05)；AKT的錶達水平與腫瘤大小,T分期,TNM分期有關(x2=4.73、4.95、5.32,P＜0.05或P＜0.01)；齣現淋巴結轉移及遠處轉移的胃癌組織中AKT(x2 =4.83、4.75,P＜0.05)、EGFR(x2=4.67,4.58,P＜0.05)錶達水平分彆較無轉移者高.結論 檢測胃癌組織中EGFR、AKT的錶達對于胃癌的診斷、疾病的分期和轉移的判斷有一定的參攷意義.
목적 탐토위암조직중표피생장인자수체(EGFR)화단백격매(AKT)표체정황여위암적림상병리특정상관성.방법 용면역조화적방법분별검측153례위암환자적암조직화암방정상위조직중EGFR、AKT적표체정도,분석기여환자림상병리특정적상관성.결과 재불동적성별、년령급불동종류병리류형、분화정도적환자중,위암조직EGFR、AKT적표체정도비교차이무통계학의의(P＞0.05).EGFR수평여TNM분기유관(x2=5.43,P＜0.05)；AKT적표체수평여종류대소,T분기,TNM분기유관(x2=4.73、4.95、5.32,P＜0.05혹P＜0.01)；출현림파결전이급원처전이적위암조직중AKT(x2 =4.83、4.75,P＜0.05)、EGFR(x2=4.67,4.58,P＜0.05)표체수평분별교무전이자고.결론 검측위암조직중EGFR、AKT적표체대우위암적진단、질병적분기화전이적판단유일정적삼고의의.
Objective To explore the association between clinical pathological characteristics and the expressions of epidermal growth factor receptor (EGFR) and protein kinase B (AKT) in gastric carcinomas.Methods The expressions of EGFR and AKT were measured with immunohistochemical method in the cancer tissues and cancer-adjacent normal tissues from 153 cases of patients with gastric cancer.The association between clinical pathological characteristics and their expressions were analyzed.Results The expressions of AKT and EGFR in gastric cancer tissues had no relationship with gender,age,pathological type,and the degree of differentiation (P ＞ 0.05).A positive correlation was existed between the EGFR and TNM stages (x2 =5.43,P ＜0.05).The AKT was positively related to the size,T stage,and TNM stage of the tumor,respectively (x2 =4.73,4.95,5.32,P ＜0.05 orP ＜0.01).The levels of AKT (x2=4.83,4.75,P ＜0.05) and EGFR(x2 =4.67,4.58,P ＜0.05) in the gastric cancer tissues with lymph node and/or distant metastasis were significantly higher than the gastric cancer tissues without metastasis,respectively.Conclusions The over-expressions of AKT and EGFR would benefit the diagnosis and stages of a gastric cancer and the determination of its metastasis.
