中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
12期
1609-1611
,共3页
西司他汀类/血液%冠状动脉疾病/血液%冠状动脉疾病/病因学
西司他汀類/血液%冠狀動脈疾病/血液%冠狀動脈疾病/病因學
서사타정류/혈액%관상동맥질병/혈액%관상동맥질병/병인학
Cystatins/blood%Coronary artery disease/blood%Coronary artery disease/etiology
目的 探讨冠状动脉粥样硬化性心脏病(CAD)患者血清胱抑素C(Cys C)水平与其病变严重程度的关系.方法 对194例行冠状动脉造影检查患者,根据结果分为冠心病组(102例)和对照组(非冠心病组92例),利用乳胶免疫增强比浊法检测两组患者血清Cys C水平并进行比较.同时将患者按血清Cys C水平＜0.67 mg/L、≥0.67 mg/L、≥0.89 mg/L和＞1.00 mg/L分为四组,比较各组的临床资料,明确血清Cys C水平与冠心病及冠脉血管病变严重程度的关系.结果 冠心病组血清Cys C水平明显高于对照组(P＜0.05),随着血清Cys C水平的升高,冠心病患者病情逐渐加重,冠状动脉病变严重程度评分增加；Logistic回归结果显示Cys C是CAD发生的独立危险因子,与CAD病变程度相关；ROC曲线分析显示,取血清Cys C水平0.79 mg/L为临界值,预测的CAD发生的灵敏度和特异性分别为76.60％和82.60％.结论 Cys C是预测CAD发生的有价值的临床指标,血清Cys C水平与冠心病有密切关系,随着血清Cys C水平升高,冠心病患者病情逐渐加重.
目的 探討冠狀動脈粥樣硬化性心髒病(CAD)患者血清胱抑素C(Cys C)水平與其病變嚴重程度的關繫.方法 對194例行冠狀動脈造影檢查患者,根據結果分為冠心病組(102例)和對照組(非冠心病組92例),利用乳膠免疫增彊比濁法檢測兩組患者血清Cys C水平併進行比較.同時將患者按血清Cys C水平＜0.67 mg/L、≥0.67 mg/L、≥0.89 mg/L和＞1.00 mg/L分為四組,比較各組的臨床資料,明確血清Cys C水平與冠心病及冠脈血管病變嚴重程度的關繫.結果 冠心病組血清Cys C水平明顯高于對照組(P＜0.05),隨著血清Cys C水平的升高,冠心病患者病情逐漸加重,冠狀動脈病變嚴重程度評分增加；Logistic迴歸結果顯示Cys C是CAD髮生的獨立危險因子,與CAD病變程度相關；ROC麯線分析顯示,取血清Cys C水平0.79 mg/L為臨界值,預測的CAD髮生的靈敏度和特異性分彆為76.60％和82.60％.結論 Cys C是預測CAD髮生的有價值的臨床指標,血清Cys C水平與冠心病有密切關繫,隨著血清Cys C水平升高,冠心病患者病情逐漸加重.
목적 탐토관상동맥죽양경화성심장병(CAD)환자혈청광억소C(Cys C)수평여기병변엄중정도적관계.방법 대194례행관상동맥조영검사환자,근거결과분위관심병조(102례)화대조조(비관심병조92례),이용유효면역증강비탁법검측량조환자혈청Cys C수평병진행비교.동시장환자안혈청Cys C수평＜0.67 mg/L、≥0.67 mg/L、≥0.89 mg/L화＞1.00 mg/L분위사조,비교각조적림상자료,명학혈청Cys C수평여관심병급관맥혈관병변엄중정도적관계.결과 관심병조혈청Cys C수평명현고우대조조(P＜0.05),수착혈청Cys C수평적승고,관심병환자병정축점가중,관상동맥병변엄중정도평분증가；Logistic회귀결과현시Cys C시CAD발생적독립위험인자,여CAD병변정도상관；ROC곡선분석현시,취혈청Cys C수평0.79 mg/L위림계치,예측적CAD발생적령민도화특이성분별위76.60％화82.60％.결론 Cys C시예측CAD발생적유개치적림상지표,혈청Cys C수평여관심병유밀절관계,수착혈청Cys C수평승고,관심병환자병정축점가중.
Objective To evaluate the relationship of serum cystatin C (Cys C) levels and the severity of coronary artery diseases (CAD).Methods A total of 194 patients underwent coronary angiography were divided into two groups (102 CAD patients) and control group (non-CAD group,92 cases).To study the relationship of the level of serum cystatin C and the severity of CAD,the serum cystatin C of all enrolled patients was detected by immune-enhancing latex turbidimetry and the serum cystatin C level of CAD group was compared to control group.Results The serum levels of cystatin C of CAD were significantly higher than the control group (P ＜ 0.05).With the increased levels of serum Cys C,CAD severity average score was increased; logistic regression analysis showed that Cys C was one of the risk factors of CAD.Cystatin C concentration was significantly correlated with CAD severity score.A cut-off value of 0.79 mg/L for cystatin C predicted incident CAD with a sensitivity of 76.60％ and specificity of 82.60％,respectively.Conclusions Serum Cys C levels are valuable clinical predictors and closely related to CAD.With the increasing levels of serum Cys C,CAD becomes more severe.
