中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
3期
321-323
,共3页
戴海鹰%林楚伟%石卓勋%赵扬程
戴海鷹%林楚偉%石卓勛%趙颺程
대해응%림초위%석탁훈%조양정
载脂蛋白A类/遗传学%载脂蛋白A类/血液%多态性,单核苷酸%代谢综合征X%心血管疾病
載脂蛋白A類/遺傳學%載脂蛋白A類/血液%多態性,單覈苷痠%代謝綜閤徵X%心血管疾病
재지단백A류/유전학%재지단백A류/혈액%다태성,단핵감산%대사종합정X%심혈관질병
Apolipoproteins A/genetics%Apolipoproteins A/blood%Polymorphism,single nucleotide%Metabolic syndrome X%Cardiovascular diseases
目的 探讨载脂蛋白A5(ApoA5)基因多态性对代谢综合征及其心血管事件发生的影响.方法 选择代谢综合征患者200例[其中未合并心血管事件患者100例(MS-1组),合并心血管事件100例(MS-2组)]和健康人100例(对照组).用ELISA法检测各组的载脂蛋白A5血清浓度,采用PCR-RFLP法测定三组的ApoA5-1131T＞C基因多态性.结果 MS-1组ApoA5血清浓度明显低于对照组[(96.68±18.09) ng/ml vs(128.32 ±23.78) ng/ml,t=10.59,P＜0.01]；MS-2组ApoA5血清浓度亦低于MS-1组[(87.67±17.09) ng/ml vs(96.68±18.09) ng/ml,t=3.62,P＜0.01]；而且MS-2组、MS-1组的ApoA5-1131C基因型频率明显高于对照组(39.4％＞30％＞16.5％,P＜0.05).结论 代谢综合征及其心血管事件患者的ApoA5血清浓度明显降低,ApoA5-1131C与代谢综合征及其心血管事件相关.
目的 探討載脂蛋白A5(ApoA5)基因多態性對代謝綜閤徵及其心血管事件髮生的影響.方法 選擇代謝綜閤徵患者200例[其中未閤併心血管事件患者100例(MS-1組),閤併心血管事件100例(MS-2組)]和健康人100例(對照組).用ELISA法檢測各組的載脂蛋白A5血清濃度,採用PCR-RFLP法測定三組的ApoA5-1131T＞C基因多態性.結果 MS-1組ApoA5血清濃度明顯低于對照組[(96.68±18.09) ng/ml vs(128.32 ±23.78) ng/ml,t=10.59,P＜0.01]；MS-2組ApoA5血清濃度亦低于MS-1組[(87.67±17.09) ng/ml vs(96.68±18.09) ng/ml,t=3.62,P＜0.01]；而且MS-2組、MS-1組的ApoA5-1131C基因型頻率明顯高于對照組(39.4％＞30％＞16.5％,P＜0.05).結論 代謝綜閤徵及其心血管事件患者的ApoA5血清濃度明顯降低,ApoA5-1131C與代謝綜閤徵及其心血管事件相關.
목적 탐토재지단백A5(ApoA5)기인다태성대대사종합정급기심혈관사건발생적영향.방법 선택대사종합정환자200례[기중미합병심혈관사건환자100례(MS-1조),합병심혈관사건100례(MS-2조)]화건강인100례(대조조).용ELISA법검측각조적재지단백A5혈청농도,채용PCR-RFLP법측정삼조적ApoA5-1131T＞C기인다태성.결과 MS-1조ApoA5혈청농도명현저우대조조[(96.68±18.09) ng/ml vs(128.32 ±23.78) ng/ml,t=10.59,P＜0.01]；MS-2조ApoA5혈청농도역저우MS-1조[(87.67±17.09) ng/ml vs(96.68±18.09) ng/ml,t=3.62,P＜0.01]；이차MS-2조、MS-1조적ApoA5-1131C기인형빈솔명현고우대조조(39.4％＞30％＞16.5％,P＜0.05).결론 대사종합정급기심혈관사건환자적ApoA5혈청농도명현강저,ApoA5-1131C여대사종합정급기심혈관사건상관.
Objective To study the effect of apolipoprotein A5 gene polymorphism on the metabolic syndrome and cardiovascular events.Methods A total of 200 patients with metabolic syndrome include 100 cases of unconsolidated cardiovascular events (MS-1 group) and 100 cases of combined cardiovascular events (MS-2 group); 100 cases of healthy people were used as control group.Apolipoprotein A5 serum concentration was detected by ELISA in each group.PCR-RFLP method was used to determine ApoA5-1131T ＞ C gene polymorphism.The automatic analyzer was used to measure fasting plasma glucose (FPG).Results The MS-1-group ApoA5 Serum concentration was significantly lower than the control group [(96.68 ± 18.09) ng/ml vs (128.32 ±23.78) ng/ml,t =10.59,P ＜0.01] ; the MS 2 groups ApoA5 serum concentrations was significantly lower than the MS-1 group [(87.67 ± 17.09) ng/rnl vs (96.68 ±18.09) ng/ml,t =3.62,P ＜0.01] ; and ApoA5-1131C genotype frequency in MS-2 group and the MS-1 group was significantly higher than the control group (39.4％ ＞ 30％ ＞ 16.5％,P ＜ 0.05).Conclusions ApoA5 serum concentrations in patients with metabolic syndrome and cardiovascular events were significantly reduced,ApoA5-1131 C was related to the metabolic syndrome and cardiovascular events.
