CAJ | 학술논문

目的筛选地佐辛预防无痛人流术后痛的最低有效剂量.方法选择同期ASA Ⅰ～Ⅱ级无痛人流术患者180例,以手术时间为序分成6组:Ⅰ组(对照组,n=30)静脉注射生理盐水2ml;Ⅱ组(n=30)静脉注射地佐辛0.01 mg/kg;Ⅲ组(n=30)静脉注射地佐辛0.02 mg/kg；Ⅳ组(n=30)静脉注射地佐辛0.03 mg/kg;Ⅴ组(n=30)静脉注射地佐辛0.04 mg/kg.Ⅵ组(n=30)静脉注射地佐辛0.05 mg/kg.观察记录各组丙泊酚用量、术中血压(BP)、心率(HR)、血氧饱和度(SpO2)、手术时间、意识恢复时间、患者离院时间、镇痛效果(VAS评分)、排便感及不良反应.结果地佐辛使用组(Ⅱ～Ⅵ组)的丙泊酚用量明显低于对照组(t=2.38,4.72,6.03,4.57,3.96,P＜0.05),而手术时间、意识恢复时间及患者离院时间比较差异无统计学意义(P＞0.05).Ⅲ、Ⅳ、Ⅴ、Ⅵ组患者术后镇痛效果以及排便感改善情况明显优于Ⅰ组,差异有统计学意义(Ⅲ组:x2=3.36,6.94,P＜0.05;Ⅳ组:x2=7.17,15.01,P＜0.05;Ⅴ组:x2 =15.5,24.3,P＜0.01;Ⅵ组:x2=13.01,20.24,P＜0.01).结论地佐辛0.05 mg/kg剂量是预防无痛人流术后痛的最低有效剂量.
목적 사선지좌신예방무통인류술후통적최저유효제량.방법 선택동기ASA Ⅰ～Ⅱ급무통인류술환자180례,이수술시간위서분성6조:Ⅰ조(대조조,n=30)정맥주사생리염수2ml;Ⅱ조(n=30)정맥주사지좌신0.01 mg/kg;Ⅲ조(n=30)정맥주사지좌신0.02 mg/kg；Ⅳ조(n=30)정맥주사지좌신0.03 mg/kg;Ⅴ조(n=30)정맥주사지좌신0.04 mg/kg.Ⅵ조(n=30)정맥주사지좌신0.05 mg/kg.관찰기록각조병박분용량、술중혈압(BP)、심솔(HR)、혈양포화도(SpO2)、수술시간、의식회복시간、환자리원시간、진통효과(VAS평분)、배편감급불량반응.결과 지좌신사용조(Ⅱ～Ⅵ조)적병박분용량명현저우대조조(t=2.38,4.72,6.03,4.57,3.96,P＜0.05),이수술시간、의식회복시간급환자리원시간비교차이무통계학의의(P＞0.05).Ⅲ、Ⅳ、Ⅴ、Ⅵ조환자술후진통효과이급배편감개선정황명현우우Ⅰ조,차이유통계학의의(Ⅲ조:x2=3.36,6.94,P＜0.05;Ⅳ조:x2=7.17,15.01,P＜0.05;Ⅴ조:x2 =15.5,24.3,P＜0.01;Ⅵ조:x2=13.01,20.24,P＜0.01).결론 지좌신0.05 mg/kg제량시예방무통인류술후통적최저유효제량.
Objective To explore the lowest and most effective dose of dezocine in preventing postoperative pain after painless artificial abortion.Methods A total of 180 ASA Ⅰ ～ Ⅱ patients who accepted painless artificial abortion were randomly divided into 6 groups (n =30 patients per group).Group 1 (control) was given the placebo (0.9％ NS; 2 ml) by vein while other groups were given dezocine by vein with 0.01 mg/kg (group 2),0.02 mg/kg (group 3),0.03 mg/kg (group 4),0.04 mg/kg (group 5),and 0.05 mg/kg (group 6),respectively.The dosage of propofol,BP,HR,SpO2 during the operation,operation time,consciousness recovery time,analgesic effect (VAS score),leaving time,defecation feeling,and untoward reaction of each group were recorded and compared.Results The dosage of propofol in the 5 dezocine groups were significantly lower than that in the control group,respectively (t =2.38,4.72,6.03,4.57,3.96,P ＜ 0.05),while the difference in the operation time,consciousness recovery time and leaving time between the 5 dezocine groups and the control group had not statistical significance (P ＞0.05).The effect of postoperative analgesia and defecation feeling were apparently improved in the group 3,4,5 and 6,compared to the control group(group 3:x2 =3.36,6.94,P ＜ 0.05;group 4:x2 =7.17,15.01,P ＜ 0.05 ; group 5:x2 =15.5,24.3,P ＜ 0.01 ; group 6:x2 =13.01,20.24,P ＜ 0.01).Conclusions The lowest and most effective dose of dezocine was 0.05 mg/kg in preventing postoperative pain after painless artificial abortion.