中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
9期
1202-1205
,共4页
核苷酸类/治疗应用%钠%伤口愈合%烧伤%外科伤口感染/药物疗法
覈苷痠類/治療應用%鈉%傷口愈閤%燒傷%外科傷口感染/藥物療法
핵감산류/치료응용%납%상구유합%소상%외과상구감염/약물요법
Nucleotides/therapeutic use%Sodium%Wound healing%Burns%Surgical wound infection/drug therapy
目的 评价脱氧核苷酸钠干预创面愈合的临床疗效.方法 纳入144例Ⅱ类切口以上的患者,按随机数字表法分为2组,每组72例.对照组于术后给予常规药物外敷、抗生素、补液、葡萄糖滴注常规治疗,同时给予胸腺五肽l mg/次,1次/d,溶于5％葡萄糖溶液或生理盐水中滴注.观察组则在常规治疗基础上给予脱氧核苷酸钠200 mg/次,1次／d.于第7、14、30天评价创面的愈合情况.结果 两组术后感染发生率比较差异无统计学意义(12.1％ vs 16.6％,P＞0.05).观察组患者较对照组具有更高的14 d完全愈合率(80％vs 48.3％,P＜0.05)、体重增加量[(2.1±0.7) kgvs (0.6 ±0.3)kg,P=0.016)]、临床总有效率(89.3％ vs 61.3％,P=0.0018),具有更少的7d遗留创面面积[(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018]和更短的创面安全愈合时间[(18.8±11.2)d vs (21.4±12.6)d,P=0.023].治疗后观察组III型前胶原水平明显高于对照组[(35.4±7.6) ng/L vs (24.4 ±6.9)ng/L,P=0.006).结论 脱氧核苷酸与胸腺五肽均能通过激活免疫,减少术后感染,但创面愈合修复与免疫提升似乎并无关联,脱氧核苷酸可通过促进成纤维细胞增殖及肉芽组织生长、迁移促进创伤的愈合.
目的 評價脫氧覈苷痠鈉榦預創麵愈閤的臨床療效.方法 納入144例Ⅱ類切口以上的患者,按隨機數字錶法分為2組,每組72例.對照組于術後給予常規藥物外敷、抗生素、補液、葡萄糖滴註常規治療,同時給予胸腺五肽l mg/次,1次/d,溶于5％葡萄糖溶液或生理鹽水中滴註.觀察組則在常規治療基礎上給予脫氧覈苷痠鈉200 mg/次,1次／d.于第7、14、30天評價創麵的愈閤情況.結果 兩組術後感染髮生率比較差異無統計學意義(12.1％ vs 16.6％,P＞0.05).觀察組患者較對照組具有更高的14 d完全愈閤率(80％vs 48.3％,P＜0.05)、體重增加量[(2.1±0.7) kgvs (0.6 ±0.3)kg,P=0.016)]、臨床總有效率(89.3％ vs 61.3％,P=0.0018),具有更少的7d遺留創麵麵積[(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018]和更短的創麵安全愈閤時間[(18.8±11.2)d vs (21.4±12.6)d,P=0.023].治療後觀察組III型前膠原水平明顯高于對照組[(35.4±7.6) ng/L vs (24.4 ±6.9)ng/L,P=0.006).結論 脫氧覈苷痠與胸腺五肽均能通過激活免疫,減少術後感染,但創麵愈閤脩複與免疫提升似乎併無關聯,脫氧覈苷痠可通過促進成纖維細胞增殖及肉芽組織生長、遷移促進創傷的愈閤.
목적 평개탈양핵감산납간예창면유합적림상료효.방법 납입144례Ⅱ류절구이상적환자,안수궤수자표법분위2조,매조72례.대조조우술후급여상규약물외부、항생소、보액、포도당적주상규치료,동시급여흉선오태l mg/차,1차/d,용우5％포도당용액혹생리염수중적주.관찰조칙재상규치료기출상급여탈양핵감산납200 mg/차,1차／d.우제7、14、30천평개창면적유합정황.결과 량조술후감염발생솔비교차이무통계학의의(12.1％ vs 16.6％,P＞0.05).관찰조환자교대조조구유경고적14 d완전유합솔(80％vs 48.3％,P＜0.05)、체중증가량[(2.1±0.7) kgvs (0.6 ±0.3)kg,P=0.016)]、림상총유효솔(89.3％ vs 61.3％,P=0.0018),구유경소적7d유류창면면적[(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018]화경단적창면안전유합시간[(18.8±11.2)d vs (21.4±12.6)d,P=0.023].치료후관찰조III형전효원수평명현고우대조조[(35.4±7.6) ng/L vs (24.4 ±6.9)ng/L,P=0.006).결론 탈양핵감산여흉선오태균능통과격활면역,감소술후감염,단창면유합수복여면역제승사호병무관련,탈양핵감산가통과촉진성섬유세포증식급육아조직생장、천이촉진창상적유합.
Objective To evaluate the efficacy and safety of deoxyribonucleotide in intervention with wound healing.Methods A total of 144 patients above Type Ⅱ incision was included.All patients were received conventional therapy.And 72 cases in positive group were given thymopentin 1mg/d for 7 ～14 days,72 patients in treatment group were given deoxyribonucleotide 200mg/d for 7 ～ 14 days.Wounds were observed at 7,14,30 days,respectively.Results Postoperative infection rate(12.1％ vs 16.6％ vs 40％,P ＜ 0.05),pathogenic bacteria detection were decreased by both treatment and control groups.The 14 d complete healing rate (80％ vs 48.3 ％,P ＜ 0.05),weight gain [(2.1 ± 0.7) kg vs (0.6 ± 0.3) kg,P=0.016],clinical effect (89.3％ vs 61.3％,P =0.0018) of treatment group were higher than the control group.The 7 d wound area and complete healing time of treatment group were lower than the control group [(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018; (18.8 ± 11.2)d vs (21.4 ± 12.6)d,P =0.023].Deoxyribonucleotide can promote fibroblast proliferation and collagen production [(35.4 ± 7.6)ng/L vs (24.4 ± 6.9) ng/L,P =0.006].Conclusions Short-term application of deoxyribonucleotide and thymopentin can decrease postoperative infection through activating immune function.However,wound healing had no relationship with activating immune function seemly.Deoxyribonucleotide promotes wound healing through promoting fibroblast proliferation.
