中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
10期
1327-1329
,共3页
邓喜成%艾祁%谭志平%刘平波%黄尔佳
鄧喜成%艾祁%譚誌平%劉平波%黃爾佳
산희성%애기%담지평%류평파%황이가
染色体缺失%综合征%染色体,人,22对%心脏缺损,先天性/遗传学%血小板
染色體缺失%綜閤徵%染色體,人,22對%心髒缺損,先天性/遺傳學%血小闆
염색체결실%종합정%염색체,인,22대%심장결손,선천성/유전학%혈소판
Chromosome deletion%Syndrome%Chromosomes,human,pair 22%Heart defects,congenital/genetics%Blood platelets
目的 探讨22q11先心病患者的血小板特征,及其在心脏手术中可能的临床应用价值.方法 选择已行心脏手术的80例患儿作为研究对象,所有患儿均经原位荧光杂交(FISH)检测明确为22q11微缺失综合征40例,阴性者40例.收集医院信息系统中患儿术前检查中血小板相关数据,进行统计学分析.结果 22q11微缺失综合征平均血小板体积明显大于对照组[(11.20±1.94)fLvs (8.95±1.58)fL,P＜0.01].平均血小板体积的接收者操作特征曲线下面积为0.82,具有预测意义.平均血小板体积(MPV)=10fL的敏感度为70.0％,特异度为80.0％.结论 22q11先心病患者平均血小板体积显著大于非22q11先心病患者,并可从血常规中获得数据,可以作为22q11的经济、快捷的初筛手段.MPV=10 fL可以作为心脏手术给辐照血的参考指标.
目的 探討22q11先心病患者的血小闆特徵,及其在心髒手術中可能的臨床應用價值.方法 選擇已行心髒手術的80例患兒作為研究對象,所有患兒均經原位熒光雜交(FISH)檢測明確為22q11微缺失綜閤徵40例,陰性者40例.收集醫院信息繫統中患兒術前檢查中血小闆相關數據,進行統計學分析.結果 22q11微缺失綜閤徵平均血小闆體積明顯大于對照組[(11.20±1.94)fLvs (8.95±1.58)fL,P＜0.01].平均血小闆體積的接收者操作特徵麯線下麵積為0.82,具有預測意義.平均血小闆體積(MPV)=10fL的敏感度為70.0％,特異度為80.0％.結論 22q11先心病患者平均血小闆體積顯著大于非22q11先心病患者,併可從血常規中穫得數據,可以作為22q11的經濟、快捷的初篩手段.MPV=10 fL可以作為心髒手術給輻照血的參攷指標.
목적 탐토22q11선심병환자적혈소판특정,급기재심장수술중가능적림상응용개치.방법 선택이행심장수술적80례환인작위연구대상,소유환인균경원위형광잡교(FISH)검측명학위22q11미결실종합정40례,음성자40례.수집의원신식계통중환인술전검사중혈소판상관수거,진행통계학분석.결과 22q11미결실종합정평균혈소판체적명현대우대조조[(11.20±1.94)fLvs (8.95±1.58)fL,P＜0.01].평균혈소판체적적접수자조작특정곡선하면적위0.82,구유예측의의.평균혈소판체적(MPV)=10fL적민감도위70.0％,특이도위80.0％.결론 22q11선심병환자평균혈소판체적현저대우비22q11선심병환자,병가종혈상규중획득수거,가이작위22q11적경제、쾌첩적초사수단.MPV=10 fL가이작위심장수술급복조혈적삼고지표.
Objective 22q11 microdeletion is featured with hemotological dysfunction,among others:hypocalcemia,thrombocytopenia and megathrombocyte.This study was trying to work out the platelet characteristics of 22q1 1 microdeletion patients and its potential clinical application.Methods A total of 80 cases who had undergone open-heart surgery were selected and confirmed with fluorescence in situ hybridization (FISH) to have 22q1 1 microdeletion among 40 cases while the others were negative.The relevant data in full blood routine of all the 80 cases in hospital information system (HIS) then were collected and analyzed with suitable statistical methods.Results The mean platelet volume in microdeletion group was statistically higher than that in the control group [(11.20 ± 1.94)fL vs (8.95 ± 1.58) fL,P ＜0.01].The area under the receiver operating characteristic (ROC) curve was 0.82,meaning significant predictive values.The corresponding sensitivity and specificity for mean platelet volume (MPV) =10 fL were 70.0 ％ and 80.0 ％,respectively.Conclusions MPV in congenital heart defect patients with 22q11 is significantly higher than those without 22q11.It is an effective method for preliminary screening 22q11.Being obtained from full blood routine data,it is economic and quick.MPV =10 fL can be used as a cutoff for guidance for irradiated blood transfusion postoperatively.
