CAJ | 학술논문

目的分析比较左右侧乳腺癌辅助放疗后缺血性心脏病发病的差别.方法回顾性调查本院2006年10月至2011年12月期间住院的105例乳腺癌术后辅助放疗患者的病历资料,记录患者的治疗前临床特征、放疗分割方案、缺血性心脏病的发生及其时间,统计分析左右侧乳腺癌放疗后缺血性心脏病发病的差异.结果治疗前年龄与缺血性心脏病发病显著相关(P＜0.05),＞ 60岁较＜ 60岁患者的发病风险增加了3.84倍(P＜0.05).左侧乳腺癌较右侧辅助放疗后缺血性心脏病发病风险有增加、提前的趋势,虽然发病风险增加了1.57倍,但差异无统计学意义(P＞0.05).10例接受调强放射治疗的患者无缺血性心脏病发生.结论左侧乳腺癌术后辅助放疗有增加缺血性心脏病发病风险的趋势.建议左侧乳腺癌术后放疗常规应用调强放射治疗减少心脏照射剂量.
목적 분석비교좌우측유선암보조방료후결혈성심장병발병적차별.방법 회고성조사본원2006년10월지2011년12월기간주원적105례유선암술후보조방료환자적병력자료,기록환자적치료전림상특정、방료분할방안、결혈성심장병적발생급기시간,통계분석좌우측유선암방료후결혈성심장병발병적차이.결과 치료전년령여결혈성심장병발병현저상관(P＜0.05),＞ 60세교＜ 60세환자적발병풍험증가료3.84배(P＜0.05).좌측유선암교우측보조방료후결혈성심장병발병풍험유증가、제전적추세,수연발병풍험증가료1.57배,단차이무통계학의의(P＞0.05).10례접수조강방사치료적환자무결혈성심장병발생.결론 좌측유선암술후보조방료유증가결혈성심장병발병풍험적추세.건의좌측유선암술후방료상규응용조강방사치료감소심장조사제량.
Objective To compare the difference in ischemic heart disease (IHD) incidence between left and right breast cancer treated with post-op radiation therapy.Methods We retrospectively reviewed electronic database of breast cancer patients treated in our cancer center from October 2006 to December 2011.Clinical data were recorded including clinical features,radiation fraction,and IHD.Statistical analysis was performed to compare the difference in IHD incidence between left and right breast cancer.Results Age on diagnosis was significantly associated with IHD (P ＜ 0.05).Compare to younger patients (≤60),the increased hazard ratio of IHD in older patients (＞60) was 3.84.The left breast cancer patients had greater incidence of IHD with the increased hazard ratio of 1.57 although this difference did not reach statistical power (P ＞ 0.05).No patients got IHD in the intensity-modulated radiation therapy group.Conclusions Left-side breast cancer patients may have more probability to get IHD after thoracic radiation therapy compared to right-side patients.We recommend that left-side breast cancer patients should be treated with intensity-modulated radiation therapy to spare heart if they receive prophylactic radiation therapy after surgery.