CAJ | 학술논문

目的观测半乳糖凝集素-3(Gal-3)在慢性心力衰竭患者中的水平及其诊断价值.方法选择慢性心力衰竭患者108例,按纽约心功能分级分成三组(Ⅱ、Ⅲ、Ⅳ级),健康对照组30例,所有病例均行心脏彩超检查,抽血检测Gal-3、B型脑利钠肽前体(NT-proBNP)及白细胞介素-6(IL-6)浓度.结果心衰组的Gal-3水平明显高于对照组(P＜0.05),与NYHA心功能分级呈正相关;相关性分析显示,Gal-3水平与NT-proBNP、IL-6呈正相关;Gal-3水平与左心室直径(LVD)、左室射血分数(LVEF)不相关.结论心衰患者血清Gal-3水平明显增高,升高水平与心衰程度显著相关;Gal-3可能作为心衰的新生化标志物,联合NT-proBNP可提高对心衰的诊断及其预后的判断.
목적 관측반유당응집소-3(Gal-3)재만성심력쇠갈환자중적수평급기진단개치.방법 선택만성심력쇠갈환자108례,안뉴약심공능분급분성삼조(Ⅱ、Ⅲ、Ⅳ급),건강대조조30례,소유병례균행심장채초검사,추혈검측Gal-3、B형뇌리납태전체(NT-proBNP)급백세포개소-6(IL-6)농도.결과 심쇠조적Gal-3수평명현고우대조조(P＜0.05),여NYHA심공능분급정정상관;상관성분석현시,Gal-3수평여NT-proBNP、IL-6정정상관;Gal-3수평여좌심실직경(LVD)、좌실사혈분수(LVEF)불상관.결론 심쇠환자혈청Gal-3수평명현증고,승고수평여심쇠정도현저상관;Gal-3가능작위심쇠적신생화표지물,연합NT-proBNP가제고대심쇠적진단급기예후적판단.
Objective To investigate serum galectin-3 levels in patients with chronic heart failure and evaluate its clinical significance for heart failure.Methods A total of 108 chronic heart failure patients were selected.The selected patients were divided into three groups according to the classification of New York Heart Association (NYHA,from degree Ⅱ to Ⅳ).In addition,30 healthy persons were chosen as control group.All the patients received cardiac ultrasound examination.Plasma levels of N-terminal probrain natriuretic peptide (NT-proBNP),serum levels of galectin-3 and interleukin-6 (IL-6) were measured and analyzed.Results Galectin-3 levels were significantly higher in chronic heart failure patients compared with control group(P ＜ 0.05).In chronic heart failure group,the increase of serum concentration of galectin-3 was correlated with the degree of NYHA function classification.Correlation analysis showed that blood level of galectin 3 was strongly positive correlation with concentration of NT-proBNP and IL-6.There was no correlation between galectin-3 with the cause of heart failure,left ventricular diameter(LVD),and left ventricular ejection fraction (LVEF).Conclusions The levels of galectin-3 was significantly increased in chronic heart failure,and was correlated with degree of heart failure.Galectin-3 might be a new biomarker of heart failure and could provide additive value to NT-proBNP levels in the diagnosis of heart failure.