CAJ | 학술논문

目的测定老年非糖尿病冠心病(CHD)患者糖化血红蛋白(HbA1c)和同型半胱氨酸(Hcy)的水平,并探讨其临床意义.方法选择老年非糖尿病CHD患者86例(急性冠脉综合征组45例和稳定型心绞痛组41例),非糖尿病非CHD患者60例为对照组,测定并比较各组HbA1c和Hcy的水平,分析两者的关系.结果老年非糖尿病CHD组HbA1c和Hcy均高于对照组,急性冠脉综合征组HbA1c和Hcy水平高于稳定型心绞痛组,差异均有统计学意义(P＜0.05);HbA1c和Hcy水平变化呈正相关(r =0.34,P＜0.05).结论在非糖尿病CHD患者中存在HbA1c和Hcy升高,且随CHD程度的加重而上升,提示HbA1c和Hcy是心血管风险的预测因子.
목적 측정노년비당뇨병관심병(CHD)환자당화혈홍단백(HbA1c)화동형반광안산(Hcy)적수평,병탐토기림상의의.방법 선택노년비당뇨병CHD환자86례(급성관맥종합정조45례화은정형심교통조41례),비당뇨병비CHD환자60례위대조조,측정병비교각조HbA1c화Hcy적수평,분석량자적관계.결과 노년비당뇨병CHD조HbA1c화Hcy균고우대조조,급성관맥종합정조HbA1c화Hcy수평고우은정형심교통조,차이균유통계학의의(P＜0.05);HbA1c화Hcy수평변화정정상관(r =0.34,P＜0.05).결론 재비당뇨병CHD환자중존재HbA1c화Hcy승고,차수CHD정도적가중이상승,제시HbA1c화Hcy시심혈관풍험적예측인자.
Objective To investigate hemoglobin A1c(HbA1c) and homocysteine (Hcy) in nondiabetic elder patients with coronary heart disease (CHD),and explore their clinical value.Methods Eighty-six non-diabetic elder patients with CHD [45 cases with acute coronary syndrome (ACS) and 41 cases with stable angina pectoris (SAP)] and sixty elder patients without diabetes mellitus and coronary heart disease as control group were selected.The plasma levels of HbA1c and Hcy in all groups were detected and analyzed.Results The levels of HbA1c and Hcy in CHD group were significantly higher than those in control group (P ＜0.05),and levels of HbA1c and Hcy in ACS group were both higher than SAP group (P＜0.05).The change of HbA1c and Hcy had positive correlation (r =0.34,P ＜0.05).Conclusions The levels of HbA1c and Hcy were higher in non-diabetic elder patients with CHD than those without CHD,and might correlate with atherosclerosis.HbA1c and Hcy might be markers of cardiovascular risk.