CAJ | 학술논문

蛛网膜下腔出血%白细胞介素1β/血液%白细胞介素1β/脑脊髓液%白细胞介素6/血液%白细胞介素6/脑脊髓液%肿瘤坏死因子α/血液%肿瘤坏死因子α/脑脊髓液%全身炎症反应综合征%多器官功能衰竭蛛網膜下腔齣血%白細胞介素1β/血液%白細胞介素1β/腦脊髓液%白細胞介素6/血液%白細胞介素6/腦脊髓液%腫瘤壞死因子α/血液%腫瘤壞死因子α/腦脊髓液%全身炎癥反應綜閤徵%多器官功能衰竭
주망막하강출혈%백세포개소1β/혈액%백세포개소1β/뇌척수액%백세포개소6/혈액%백세포개소6/뇌척수액%종류배사인자α/혈액%종류배사인자α/뇌척수액%전신염증반응종합정%다기관공능쇠갈
Subarachnoid hemorrhage%Interleukin-1 beta/blood%Interleukin-1 beta/cerebrospinal fluid%Interleukin-6/blood%Interleukin-6/cerebrospinal fluid%Tumor necrosis factor-alpha/blood%Tumor necrosis factor-alpha/cerebrospinal fluid%Systemic inflammatory re

目的探讨自发性蛛网膜下腔出血(SAH)后血清和脑脊液细胞因子水平及其与全身炎症反应综合征(SIRS)和多器官功能障碍综合征(MODS)关系.方法选用双抗体夹心酶联免疫吸附试验(ELISA)检测自发性SAH患者血清和脑脊液IL-1β、IL-6和TNF-α浓度.结果自发性蛛网膜下腔出血后血清和脑脊液IL-1β、IL-6和TNF-α水平均显著升高(P＜0.01),但增高时段不同.血清IL-1β、IL-6和TNF-α水平与SIRS和MODS的发生有关(P＜0.05);脑脊液IL-1β、IL-6水平与SIRS和MODS的发生有关(P＜0.05),但TNF-α水平与SIRS及MODS无关(P＞0.05).结论自发性SAH患者血清IL-1β、IL-6和TNF-α水平及脑脊液IL-1β、IL-6水平增高可能与SIRS及MODS有关,检测自发性SAH患者血清IL-1β、IL-6和TNF-α水平及脑脊液IL-1β、IL-6水平可为预测SIRS和MODS及指导治疗提供依据.
목적 탐토자발성주망막하강출혈(SAH)후혈청화뇌척액세포인자수평급기여전신염증반응종합정(SIRS)화다기관공능장애종합정(MODS)관계.방법 선용쌍항체협심매련면역흡부시험(ELISA)검측자발성SAH환자혈청화뇌척액IL-1β、IL-6화TNF-α농도.결과 자발성주망막하강출혈후혈청화뇌척액IL-1β、IL-6화TNF-α수평균현저승고(P＜0.01),단증고시단불동.혈청IL-1β、IL-6화TNF-α수평여SIRS화MODS적발생유관(P＜0.05);뇌척액IL-1β、IL-6수평여SIRS화MODS적발생유관(P＜0.05),단TNF-α수평여SIRS급MODS무관(P＞0.05).결론 자발성SAH환자혈청IL-1β、IL-6화TNF-α수평급뇌척액IL-1β、IL-6수평증고가능여SIRS급MODS유관,검측자발성SAH환자혈청IL-1β、IL-6화TNF-α수평급뇌척액IL-1β、IL-6수평가위예측SIRS화MODS급지도치료제공의거.
Objective To explore the levels of IL-1β,IL-6 and tumor necrosis factor α (TNF α) in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage and their relationship with systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS).Methods The levels of interleukin-1β(IL-1β),interleukin-6(IL-6),and TNF α in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage were measured with enzyme-linked immunosorbent assay (ELISA).Results The levels of IL-1β,IL-6,and TNFα in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage were significantly higher than those of control group (P ＜ 0.05),but the increased time of these cytokines was different.Three cytokines in serum and the cerebrospinal fluid levels of IL-1β and IL-6 but not TNFα were significantly related to SIRS and MODS.Condusions The increased cytokine levels in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage may be related to SIRS and MODS,and the measurement of IL-1β,IL-6,and TNFαin serum,and IL-1β and IL-6 in cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage can be useful to predict and treat SIRS and MODS.