CAJ | 학술논문

目的采用三种不同代谢综合征建议诊断标准,观察新疆糖维吾尔族代谢异常人群代谢综合征的患病率、检查率差异以及代谢综合征组分数目累积对血脂谱的影响.方法采用分层整群随机抽样获得666例维吾尔族糖代谢异常人群,采用2001年美国国家胆固醇教育计划第三次报告(NcEP-ATPⅢ)、2004年中华医学会糖尿病学分会(CDS)和2005年国际糖尿病联盟(IDF)的代谢综合征建议诊断标准分析其代谢综合征组分和血脂谱.结果 ATPⅢ(2001)、CDS(2004)、IDF(2005)诊断标准下代谢综合征的患病率(标化患病率)分别为21.92％(14.67％),23.72％(15.88％),57.51％ (38.48％);IDF(2005)诊断优于其他两种标准(P＜0.05).ATPⅢ(2001)标准下,随着代谢综合征组分数目的增加,高密度脂蛋白胆固醇水平下降,低密度脂蛋白胆固醇水平升高;CDS(2004)标准下,各项血脂变化差异无统计学意义(P＞0.05);IDF(2005)标准下,甘油三酯水平显著升高.结论三种诊断标准下,维吾尔族糖代谢异常人群中均有较高的代谢综合征患病率;代谢异常均伴有血脂异常;表现为容易导致心血管疾病的血脂谱,即甘油三酯水平升高、高密度脂蛋白胆固醇水平降低和低密度脂蛋白胆固醇水平升高.
목적 채용삼충불동대사종합정건의진단표준,관찰신강당유오이족대사이상인군대사종합정적환병솔、검사솔차이이급대사종합정조분수목루적대혈지보적영향.방법 채용분층정군수궤추양획득666례유오이족당대사이상인군,채용2001년미국국가담고순교육계화제삼차보고(NcEP-ATPⅢ)、2004년중화의학회당뇨병학분회(CDS)화2005년국제당뇨병련맹(IDF)적대사종합정건의진단표준분석기대사종합정조분화혈지보.결과 ATPⅢ(2001)、CDS(2004)、IDF(2005)진단표준하대사종합정적환병솔(표화환병솔)분별위21.92％(14.67％),23.72％(15.88％),57.51％ (38.48％);IDF(2005)진단우우기타량충표준(P＜0.05).ATPⅢ(2001)표준하,수착대사종합정조분수목적증가,고밀도지단백담고순수평하강,저밀도지단백담고순수평승고;CDS(2004)표준하,각항혈지변화차이무통계학의의(P＞0.05);IDF(2005)표준하,감유삼지수평현저승고.결론 삼충진단표준하,유오이족당대사이상인군중균유교고적대사종합정환병솔;대사이상균반유혈지이상;표현위용역도치심혈관질병적혈지보,즉감유삼지수평승고、고밀도지단백담고순수평강저화저밀도지단백담고순수평승고.
Objective To study the prevalence of metabolic syndrome (MS) within the Uyghur people with abnormal glucose metabolism in Xinjiang province according to three different diagnostic criteria and effects of accumulation of MS components on blood lipid profile.Methods Components of MS and blood lipid profile were observed with 666 Uyghur people with abnormal glucose metabolism after cluster randomized sampling method for selecting in Xinjiang province,and analyzed with the recommended diagnostic criteria by the National Cholesterol Education Program-Adult treatment Panel Ⅲ(NCEP-ATP Ⅲ,2001),the Chinese Diabetes Society under Chinese Medical Association (CDS,2004) and the International Diabetes Federation (IDF,2005).Results Prevalence of MS was 21.92％ (14.67％),23.72％ (15.88％),57.51％ (38.48％) with the criteria by NCEP-ATPⅢ,CDS,and IDF,respectively.IDF was the best among three criteria.The most combination was the abnormal glucose metabolism,dyslipidemia and obesity.In the ATPⅢ (2001),with the increase of number of components of metabolic syndrome,highdensity lipoprotein cholesterol (HDL-C) drop,low density lipoprotein cholesterol (LDL-C) increased; there was not significant difference in the CDS.Conclusions The incidence of MS was high in the Uyghur people with abnormal glucose metabolism in Xinjiang province.Most of them complicated with dyslipidemia.One of common components of MS included the elevated triglycerides,decreased HDL-C,and increased size of LDL-C particles,which could easily cause cardiovascular disease.