中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
11期
1502-1504
,共3页
心绞痛,不稳定型%血管成形术,经腔,经皮冠状动脉%烟酰胺磷酸核糖基转移酶/血液%肌钙蛋白Ⅰ/血液
心絞痛,不穩定型%血管成形術,經腔,經皮冠狀動脈%煙酰胺燐痠覈糖基轉移酶/血液%肌鈣蛋白Ⅰ/血液
심교통,불은정형%혈관성형술,경강,경피관상동맥%연선알린산핵당기전이매/혈액%기개단백Ⅰ/혈액
Angina,unstable%Angioplasty,transluminal,percutaneous coronary%Nicotinamide phosphoribosyltransferase/blood%Troponin Ⅰ/blood
目的 探讨不稳定性心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)前后血清内脂素(Visfatin)及肌钙蛋白Ⅰ(cardiac Troponin Ⅰ,cTnI)水平变化及临床意义.方法 选择108例UAP经PCI的患者,分别在术前,术后24、72 h及30 d测定血清Visfatin水平及cTnI水平.入选同期52例冠脉造影正常者作为对照组.随访3年,观察术后主要心脏不良事件(MACE)发生与Visfatin和cTnI水平之间的关系.结果 UAP患者Visfatin和cTnI水平PCI术后24h较术前明显升高(P=0.01);Visfatin水平在术后30 d与术前差异无统计学意义(P=0.12);cTnI水平在术后30 d显著低于术前水平(P=0.02);Visfatin与cTnI水平呈正相关(r=0.523,P=0.01);发生MACE的PCI患者术后血清Visfatin与cTnI水平明显高于未发生MACE患者(P=0.03);Visfatin与cTnI是MACE独立危险因素(OR=3.27,2.85,P＜0.05).结论 UAP患者PCI术后血清Visfatin与cTnI水平均一过性升高,且与发生MACE相关,两者在UAP患者PCI术后发生MACE的预测方面均有一定价值.
目的 探討不穩定性心絞痛(UAP)患者經皮冠狀動脈介入治療(PCI)前後血清內脂素(Visfatin)及肌鈣蛋白Ⅰ(cardiac Troponin Ⅰ,cTnI)水平變化及臨床意義.方法 選擇108例UAP經PCI的患者,分彆在術前,術後24、72 h及30 d測定血清Visfatin水平及cTnI水平.入選同期52例冠脈造影正常者作為對照組.隨訪3年,觀察術後主要心髒不良事件(MACE)髮生與Visfatin和cTnI水平之間的關繫.結果 UAP患者Visfatin和cTnI水平PCI術後24h較術前明顯升高(P=0.01);Visfatin水平在術後30 d與術前差異無統計學意義(P=0.12);cTnI水平在術後30 d顯著低于術前水平(P=0.02);Visfatin與cTnI水平呈正相關(r=0.523,P=0.01);髮生MACE的PCI患者術後血清Visfatin與cTnI水平明顯高于未髮生MACE患者(P=0.03);Visfatin與cTnI是MACE獨立危險因素(OR=3.27,2.85,P＜0.05).結論 UAP患者PCI術後血清Visfatin與cTnI水平均一過性升高,且與髮生MACE相關,兩者在UAP患者PCI術後髮生MACE的預測方麵均有一定價值.
목적 탐토불은정성심교통(UAP)환자경피관상동맥개입치료(PCI)전후혈청내지소(Visfatin)급기개단백Ⅰ(cardiac Troponin Ⅰ,cTnI)수평변화급림상의의.방법 선택108례UAP경PCI적환자,분별재술전,술후24、72 h급30 d측정혈청Visfatin수평급cTnI수평.입선동기52례관맥조영정상자작위대조조.수방3년,관찰술후주요심장불량사건(MACE)발생여Visfatin화cTnI수평지간적관계.결과 UAP환자Visfatin화cTnI수평PCI술후24h교술전명현승고(P=0.01);Visfatin수평재술후30 d여술전차이무통계학의의(P=0.12);cTnI수평재술후30 d현저저우술전수평(P=0.02);Visfatin여cTnI수평정정상관(r=0.523,P=0.01);발생MACE적PCI환자술후혈청Visfatin여cTnI수평명현고우미발생MACE환자(P=0.03);Visfatin여cTnI시MACE독립위험인소(OR=3.27,2.85,P＜0.05).결론 UAP환자PCI술후혈청Visfatin여cTnI수평균일과성승고,차여발생MACE상관,량자재UAP환자PCI술후발생MACE적예측방면균유일정개치.
Objective To investigate the changes and clinical significance of serum visfatin and cardiac troponin I (cTnI) level in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI).Methods The 108 patients (aged 51 ～80 years) with UAP and 52 healthy subjects (aged 48 ～ 75) were enrolled.Before and after PCI at the different time,the serum levels of visfatin and cTnI were analyzed.During three years followed-up,the major adverse cardiac events (MACE) were assessed.MACE defined as cardiac death,myocardial infarction,target lesion revascularization anginal status.Results Twenty four hours later after PCI,compared with the level before PCI,the serum visfatin and cTnI levels of the UAP group were significantly increased (P =0.01) ; the serum Visfatin levels of the UAP group before PCI and 30 days later after PCI had no significant difference(P =0.12) ; Thirty days later after PCI,the serum cTnI levels of the UAP group were lower than them before PCI (P =0.02) ; high level visfatin and cTnI were independent predictors of MACE in UAP after PCI (OR =3.27,2.85) (P ＜0.05).The serum cTnI and visfatin levels were significantly positive correlation (r =0.523,P =0.01).Conclusions The serum visfatin and cTnI levels in patients with UAP after PCI increased transitorily,and they had certain value in predicting MACE.
