中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
11期
1522-1525
,共4页
曹景强%刘李继%石坚%张朝跃
曹景彊%劉李繼%石堅%張朝躍
조경강%류리계%석견%장조약
表皮生长因子%迟效制剂%聚合物%聚乙醇酸%乳酸%微球体
錶皮生長因子%遲效製劑%聚閤物%聚乙醇痠%乳痠%微毬體
표피생장인자%지효제제%취합물%취을순산%유산%미구체
Epidermal growth factor%Delayed-action preparations%Polymers%Polyglycolic acid%Lactic acid%Microspheres
目的 制备出包含重组人表皮生长因子的缓释微球,并对微球的体外释放效果进行评价.方法 采用复乳-溶剂挥发法(W/O/W)以乳酸-羟基乙酸共聚物(PLGA)为载体材料,制备人血白蛋白(HSA)微球,单因素法考察微球的粒径和包封率的影响因素.再通过正交设计出实验优化方案,再对优化微球进行性质和体外释放的研究.结果 (1)复乳-溶剂挥发法制备微球工艺稳定.(2)PLGA浓度、分子量、聚合比对微球释药速率和缓释周期有重要影响.(3)微球的粒径和载药量对突释效应有明显影响.(4)优化重组人表皮生长因子rhEGF缓释微球成圆球形,形态规则,粒径呈正态分布.微球在体外可缓释25 d以上,释放曲线符合Higuchi方程.结论 本实验制备出的优化rhEGF缓释微球形态良好,粒径分布均匀,重现性好,具有良好的体外释放性能.
目的 製備齣包含重組人錶皮生長因子的緩釋微毬,併對微毬的體外釋放效果進行評價.方法 採用複乳-溶劑揮髮法(W/O/W)以乳痠-羥基乙痠共聚物(PLGA)為載體材料,製備人血白蛋白(HSA)微毬,單因素法攷察微毬的粒徑和包封率的影響因素.再通過正交設計齣實驗優化方案,再對優化微毬進行性質和體外釋放的研究.結果 (1)複乳-溶劑揮髮法製備微毬工藝穩定.(2)PLGA濃度、分子量、聚閤比對微毬釋藥速率和緩釋週期有重要影響.(3)微毬的粒徑和載藥量對突釋效應有明顯影響.(4)優化重組人錶皮生長因子rhEGF緩釋微毬成圓毬形,形態規則,粒徑呈正態分佈.微毬在體外可緩釋25 d以上,釋放麯線符閤Higuchi方程.結論 本實驗製備齣的優化rhEGF緩釋微毬形態良好,粒徑分佈均勻,重現性好,具有良好的體外釋放性能.
목적 제비출포함중조인표피생장인자적완석미구,병대미구적체외석방효과진행평개.방법 채용복유-용제휘발법(W/O/W)이유산-간기을산공취물(PLGA)위재체재료,제비인혈백단백(HSA)미구,단인소법고찰미구적립경화포봉솔적영향인소.재통과정교설계출실험우화방안,재대우화미구진행성질화체외석방적연구.결과 (1)복유-용제휘발법제비미구공예은정.(2)PLGA농도、분자량、취합비대미구석약속솔화완석주기유중요영향.(3)미구적립경화재약량대돌석효응유명현영향.(4)우화중조인표피생장인자rhEGF완석미구성원구형,형태규칙,립경정정태분포.미구재체외가완석25 d이상,석방곡선부합Higuchi방정.결론 본실험제비출적우화rhEGF완석미구형태량호,립경분포균균,중현성호,구유량호적체외석방성능.
Objective To prepare poly (lactic-co-glycolic acid) (PLGA) microspheres that contain recombinant epidermal growth factor and then evaluate the effect of these sustained release in vitro.Methods Human serum albumin (HAS) microspheres were prepared with a double-emulsification solvent evaporation method.Experiment was designed to optimize the preparation condition of recombinant human epidermal growth factor (rhEGF)-loaded microspheres.Characters of optimal rhEGF-loaded microspheres were analyzed.In-vitro dissolution tests were performed on the microsperes.Results The speed of first emulsification,the concentration of PLGA,the concentration of polyvinyl alcohol (PVA),and the ratio of inner water to organic phase affected the particle size and the encapsulation ratio.The polymer's individual specificities especially density,molecular weight,polymerization,the diameter of microsphere,and the encapsulation efficiency were the crucial factors to influence the speed and time of drug release from microspheres in vitro.The optimal microspheres possessed a smooth and round appearance.It also showed good lente liberantes effect in vitro.Conclusions The optimal microspheres possessed a smooth and round stable appearance and showed good lente liberantes effect in vitro.This technique was simple and had a good reproducibility.