中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
11期
1526-1529
,共4页
马玲%张金国%尉希清%陈猛%谭洪勇
馬玲%張金國%尉希清%陳猛%譚洪勇
마령%장금국%위희청%진맹%담홍용
冠状血管%血流动力学%心肌缺血%综合征%内皮缩血管肽类/血液%抗凝血酶类/分析%凝血酶/分析%C反应蛋白质/分析%冠状血管造影术
冠狀血管%血流動力學%心肌缺血%綜閤徵%內皮縮血管肽類/血液%抗凝血酶類/分析%凝血酶/分析%C反應蛋白質/分析%冠狀血管造影術
관상혈관%혈류동역학%심기결혈%종합정%내피축혈관태류/혈액%항응혈매류/분석%응혈매/분석%C반응단백질/분석%관상혈관조영술
Coronary vessels%Hemodynamics%Myocardial ischemia%Syndrome%Endothelins/blood%Antithrombins/analysis%Thrombin/analysis%C-reactive protein/analysis%Coronary angiography
目的 观察冠状动脉慢血流综合征(SCFS)与血浆内皮素(ET-1)、凝血酶抗凝血酶复合物(TAT)、高敏C反应蛋白(hs-CRP)水平之间的相关性,探讨冠状动脉内皮功能、凝血功能、炎症反应对冠状动脉血流的影响.方法 随机选择400例行冠脉造影(CAG)显示冠状动脉无明显病变的患者,通过校正TIMI血流计帧法(cTFC)计算各支冠状动脉的血流帧数.筛查出SCFS患者45例,作为研究组;随机选择另外45例无SCFS的患者为对照组.应用t检验和x2检验比较两组临床资料的差异,并采用logistic回归分析SCFS的高危因素.结果 研究组的高密度脂蛋白明显低于对照组[(1.22±0.42) mmol/L vs(1.44±0.34) mmol/L,t=-2.731,P＜0.01],血糖水平明显高于对照组[(5.68 ±0.62) mmol/L vs(5.10 ±0.84) mmol/L,t=3.727,P＜0.01],血浆ET-1、TAT、hs-CRP水平高于对照组[(94.3±16.78) ng/L vs (83.5±12.53) ng/L,t=3.051,P＜0.01;(12.96 ±3.24) μg/Lvs (8.76 ±2.64) μg/L,t =5.945,P＜0.01; (2.48 ±0.35) μg/L vs(1.38 ±0.46) μg/L,t=11.259,P ＜0.01],logistic回归分析表明吸烟、血清胆固醇、ET-1、TAT、hs-CRP是影响SCFS的危险因素(OR＞1.22).结论 由于冠状动脉的内皮功能障碍以及炎症反应,出现动脉硬化,导致凝血功能活化,冠状动脉出现慢血流.
目的 觀察冠狀動脈慢血流綜閤徵(SCFS)與血漿內皮素(ET-1)、凝血酶抗凝血酶複閤物(TAT)、高敏C反應蛋白(hs-CRP)水平之間的相關性,探討冠狀動脈內皮功能、凝血功能、炎癥反應對冠狀動脈血流的影響.方法 隨機選擇400例行冠脈造影(CAG)顯示冠狀動脈無明顯病變的患者,通過校正TIMI血流計幀法(cTFC)計算各支冠狀動脈的血流幀數.篩查齣SCFS患者45例,作為研究組;隨機選擇另外45例無SCFS的患者為對照組.應用t檢驗和x2檢驗比較兩組臨床資料的差異,併採用logistic迴歸分析SCFS的高危因素.結果 研究組的高密度脂蛋白明顯低于對照組[(1.22±0.42) mmol/L vs(1.44±0.34) mmol/L,t=-2.731,P＜0.01],血糖水平明顯高于對照組[(5.68 ±0.62) mmol/L vs(5.10 ±0.84) mmol/L,t=3.727,P＜0.01],血漿ET-1、TAT、hs-CRP水平高于對照組[(94.3±16.78) ng/L vs (83.5±12.53) ng/L,t=3.051,P＜0.01;(12.96 ±3.24) μg/Lvs (8.76 ±2.64) μg/L,t =5.945,P＜0.01; (2.48 ±0.35) μg/L vs(1.38 ±0.46) μg/L,t=11.259,P ＜0.01],logistic迴歸分析錶明吸煙、血清膽固醇、ET-1、TAT、hs-CRP是影響SCFS的危險因素(OR＞1.22).結論 由于冠狀動脈的內皮功能障礙以及炎癥反應,齣現動脈硬化,導緻凝血功能活化,冠狀動脈齣現慢血流.
목적 관찰관상동맥만혈류종합정(SCFS)여혈장내피소(ET-1)、응혈매항응혈매복합물(TAT)、고민C반응단백(hs-CRP)수평지간적상관성,탐토관상동맥내피공능、응혈공능、염증반응대관상동맥혈류적영향.방법 수궤선택400례행관맥조영(CAG)현시관상동맥무명현병변적환자,통과교정TIMI혈류계정법(cTFC)계산각지관상동맥적혈류정수.사사출SCFS환자45례,작위연구조;수궤선택령외45례무SCFS적환자위대조조.응용t검험화x2검험비교량조림상자료적차이,병채용logistic회귀분석SCFS적고위인소.결과 연구조적고밀도지단백명현저우대조조[(1.22±0.42) mmol/L vs(1.44±0.34) mmol/L,t=-2.731,P＜0.01],혈당수평명현고우대조조[(5.68 ±0.62) mmol/L vs(5.10 ±0.84) mmol/L,t=3.727,P＜0.01],혈장ET-1、TAT、hs-CRP수평고우대조조[(94.3±16.78) ng/L vs (83.5±12.53) ng/L,t=3.051,P＜0.01;(12.96 ±3.24) μg/Lvs (8.76 ±2.64) μg/L,t =5.945,P＜0.01; (2.48 ±0.35) μg/L vs(1.38 ±0.46) μg/L,t=11.259,P ＜0.01],logistic회귀분석표명흡연、혈청담고순、ET-1、TAT、hs-CRP시영향SCFS적위험인소(OR＞1.22).결론 유우관상동맥적내피공능장애이급염증반응,출현동맥경화,도치응혈공능활화,관상동맥출현만혈류.
Objective To investigate the relationship between the plasma levels of ET-1,TAT,and hs-CRP and slow coronary flow syndrome (SCFS),and explore effects of coronary endothelial function,coagulation function,and inflammatory reaction on blood flow of coronary artery.Methods A total of 400 cases with normal blood flow of coronary artery by coronary angiogram was randomly selected.The coronary flow patterns were determined by corrected thrombolysis in myocardial infarction frame count method (cT-FC).Among them,45 cases whose average cTFC more than 27 were assigned as SCFS group,the other 45 cases no SCFS.Plasma levels of ET-1,TAT and hs-CRPwere examined with enzyme-linked immunosorbent assay (ELISA),and were compared between two groups.Moreover,multivariate analysis evaluating predictors of SCFS was performed with regression test.Results No statistical difference was found between two groups concerning the gender,history of hypertension,diabetes mellitus,and cigarette alcohol percentage..The plasma level of HDL in SCFS group was lower than that of no SCFS [(1.22 ± 0.42) mmol/L vs (1.44±0.34) mmol/L,t =-2.731,P ＜0.01],but the plasma level of glucose in the former was higher than that of the latter [(5.68 ±0.62) mmol/L vs (5.10 ±0.84) mmol/L,t =3.727,P ＜0.01].However,Plasma levels of ET-1,TAT and hs-CRP in SCFS were higher than that of no SCFS [(94.3 ± 16.78) ng/Lvs (83.5±12.53) ng/L,t =3.051,P ＜0.01;(12.96±3.24)μg/Lvs (8.76 ±2.64)μg/L,t =5.945,P ＜ 0.01 ; (2.48 ± 0.35) μg/L vs (1.38 ± 0.46) μg/L,t =11.259,P ＜ 0.01].Furthermore,Logistic regression analysis showed that ET-1,TAT and hs-CRP were risk factors for SCFS (OR ＞ 1.22).Conclusions Due to coronary endothelial dysfunction,endothelial inflammatory reaction,and activated coagulation function,slow coronary flow of coronary artery occurs.
