CAJ | 학술논문

目的探讨18F-FDG PET-CT在淋巴瘤相关噬血细胞综合征(LAHS)诊断中的应用.方法回顾性分析30例噬血细胞综合征(HPS)患者资料,均行18F-FDG PET-CT检测,与最终经病理结果进行比较,计算18F-FDG PET-CT诊断LAHS的敏感度、特异度、阳性预测值和阴性预测值,并分析LAHS在PET-CT中的显像特点.结果 30例HPS患者中18F-FDG PET-CT诊断LAHS的灵敏度为85.71％(12/14),特异度为93.75％(15/16),阳性预测值为92.31％(12/13),阴性预测值为88.24％(15/7).18F-FDG PET-CT对于T、B细胞LAHS的检出率差异无统计学意义(P=0.066).LAHS浅表淋巴结常以锁骨上淋巴结累及为主.而在深部组织器官中,脾为最常累及部位,其次为肝、腹腔腹膜后淋巴结及骨髓.结论在HPS确诊情况下,18F-FDG PET-CT检出LAHS具有较高的敏感度和特异度,可为LAHS的诊断、指导治疗提供更多有价值的信息.
목적 탐토18F-FDG PET-CT재림파류상관서혈세포종합정(LAHS)진단중적응용.방법 회고성분석30례서혈세포종합정(HPS)환자자료,균행18F-FDG PET-CT검측,여최종경병리결과진행비교,계산18F-FDG PET-CT진단LAHS적민감도、특이도、양성예측치화음성예측치,병분석LAHS재PET-CT중적현상특점.결과 30례HPS환자중18F-FDG PET-CT진단LAHS적령민도위85.71％(12/14),특이도위93.75％(15/16),양성예측치위92.31％(12/13),음성예측치위88.24％(15/7).18F-FDG PET-CT대우T、B세포LAHS적검출솔차이무통계학의의(P=0.066).LAHS천표림파결상이쇄골상림파결루급위주.이재심부조직기관중,비위최상루급부위,기차위간、복강복막후림파결급골수.결론 재HPS학진정황하,18F-FDG PET-CT검출LAHS구유교고적민감도화특이도,가위LAHS적진단、지도치료제공경다유개치적신식.
Objective To explore the diagnostic value of 18F-FDG PET-CT in lymphoma associated hemophagocytic syndrome (HSP).Methods Retrospective analysis of 30 patients with HPS who underwent 18F-FDG PET-CT detection,and was also compared to pathologically confirmed lymphoma associated HPS to evaluate its diagnostic sensitivity,specificity,positive predictive value and negative predictive value,and to analyze the characteristics of PET-CT imaging in lymphoma associated HPS.Results In the 30 patients,the sensitivity,specificity,positive predictive value and negative predictive value in detecting lymphoma associated HPS by 18F-FDG PET-CT were 85.71％ (12/14),93.75 ％ (15/16),92.31％ (12/13) and 88.24 ％(15/17),respectively.The sensitivities of PET-CT between T-cell and B-cell lymphoma related HPS had no significant difference (P =0.066).In superficial lymph nodes,supraclavicular lymph nodes were the most commonly involved.In deeper tissues and organs,spleen was the most commonly involved site,followed by liver,abdominal retroperitoneal lymph nodes and bone marrow.Conclusion 18F-FDG PET-CT has a high sensitivity and specificity in the detection of lymphoma associated HPS,and may provide valuable information for diagnosis and treatment.