CAJ | 학술논문

目的探讨粒细胞肉瘤(GS)的临床表现、病理诊断、治疗方法及预后.方法回顾性分析10例GS患者的临床资料.结果 10例确诊为GS的患者中,5例为原发性GS,1例为急性早幼粒细胞白血病,3例为慢性髓细胞白血病,1例为骨髓增生异常综合征.所有患者采用手术、化疗或者伊马替尼治疗.1例失访；2例生存,其中1例使用含大剂量阿糖胞苷化疗方案的患者生存66个月；7例死亡,死亡患者的生存期为4～ 17个月.结论 GS临床罕见,细胞形态学检查及免疫组织化学检查对其准确诊断非常必要.GS临床预后差,急性髓细胞白血病样化疗方案为该病的主要治疗方法,高强度的化疗及造血干细胞移植治疗可以延长患者生存期.
목적 탐토립세포육류(GS)적림상표현、병리진단、치료방법급예후.방법 회고성분석10례GS환자적림상자료.결과 10례학진위GS적환자중,5례위원발성GS,1례위급성조유립세포백혈병,3례위만성수세포백혈병,1례위골수증생이상종합정.소유환자채용수술、화료혹자이마체니치료.1례실방；2례생존,기중1례사용함대제량아당포감화료방안적환자생존66개월；7례사망,사망환자적생존기위4～ 17개월.결론 GS림상한견,세포형태학검사급면역조직화학검사대기준학진단비상필요.GS림상예후차,급성수세포백혈병양화료방안위해병적주요치료방법,고강도적화료급조혈간세포이식치료가이연장환자생존기.
Objective To explore the clinical characteristics,diagnosis,therapy and prognostic features of granulocytic sarcoma (GS).Methods Retrospective analysis was used to analyse 10 cases who were diagnosed with GS.Results Five patients were diagnosed with primary GS.GS was accompanied by APL in one case,CML in 3 cases and MDS in one case.Patients were treated with resection and chemotherapy,or imatinib treatment.Follow-up data were available from 9 patients,with 2 patients being still alive.The survival of one patient who received high-dose cytarabine chemotherapy was 66 months.The other 7patients died of tumor-related diseases,and their survival ranged from 4 to 17 months.Conclusion GS is a rarely diagnosed disease.A correct diagnosis of GS depends on detailed morphological examination and immunohistochemical study.The clinical outcome of patients is poor,and AML-type chemotherapy is the proper treatment for GS.High-intensity chemotherapy and hematopoietic stem cell transplantation might improve long-term survival.