白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2013年
5期
291-293
,共3页
白血病,髓样,急性%药物疗法%阿糖胞苷%未成熟网织红细胞分数
白血病,髓樣,急性%藥物療法%阿糖胞苷%未成熟網織紅細胞分數
백혈병,수양,급성%약물요법%아당포감%미성숙망직홍세포분수
Leukemia,myeloid,acute%Drug therapy%Cytarabine%Immature reticulocyte fraction
目的 探讨急性髓系白血病(AML)患者在接受大剂最阿糖胞苷巩固化疗后骨髓抑制和恢复过程中包括未成熟网织红细胞分数(IRF)在内的外周血各参数的变化及其临床意义.方法 采用全自动血细胞分析仪动态检测30例AML患者接受大剂量阿糖胞苷巩固化疗前后外周血中性粒绍胞绝对计数(ANC)、血小板计数(Plt)和1RF,并对各个参数的变化进行分析比较.结果 患者巩固化疗后,ANC、Plt和IRF平均恢复时间分别为(9.2±2.5)d、(11.3±3.7)d和(5.0±2.6)d,IRF恢复时间短于ANC和Plt回升时间(P＜0.05),而ANC恢复时间短于Plt回升时间(P＜0.05).小同FAB分型患者间及基于细胞遗传学和分了生物学危险因素分层患者间ANC、Plt和IRF平均恢复时间差异均无统计学意义(P＞0.05).结论 IRF是AML患者接受大剂量阿糖胞苷巩固化疗后提示骨髓造血功能恢复的早期指标,对于评估疗效具有重要临床意义.
目的 探討急性髓繫白血病(AML)患者在接受大劑最阿糖胞苷鞏固化療後骨髓抑製和恢複過程中包括未成熟網織紅細胞分數(IRF)在內的外週血各參數的變化及其臨床意義.方法 採用全自動血細胞分析儀動態檢測30例AML患者接受大劑量阿糖胞苷鞏固化療前後外週血中性粒紹胞絕對計數(ANC)、血小闆計數(Plt)和1RF,併對各箇參數的變化進行分析比較.結果 患者鞏固化療後,ANC、Plt和IRF平均恢複時間分彆為(9.2±2.5)d、(11.3±3.7)d和(5.0±2.6)d,IRF恢複時間短于ANC和Plt迴升時間(P＜0.05),而ANC恢複時間短于Plt迴升時間(P＜0.05).小同FAB分型患者間及基于細胞遺傳學和分瞭生物學危險因素分層患者間ANC、Plt和IRF平均恢複時間差異均無統計學意義(P＞0.05).結論 IRF是AML患者接受大劑量阿糖胞苷鞏固化療後提示骨髓造血功能恢複的早期指標,對于評估療效具有重要臨床意義.
목적 탐토급성수계백혈병(AML)환자재접수대제최아당포감공고화료후골수억제화회복과정중포괄미성숙망직홍세포분수(IRF)재내적외주혈각삼수적변화급기림상의의.방법 채용전자동혈세포분석의동태검측30례AML환자접수대제량아당포감공고화료전후외주혈중성립소포절대계수(ANC)、혈소판계수(Plt)화1RF,병대각개삼수적변화진행분석비교.결과 환자공고화료후,ANC、Plt화IRF평균회복시간분별위(9.2±2.5)d、(11.3±3.7)d화(5.0±2.6)d,IRF회복시간단우ANC화Plt회승시간(P＜0.05),이ANC회복시간단우Plt회승시간(P＜0.05).소동FAB분형환자간급기우세포유전학화분료생물학위험인소분층환자간ANC、Plt화IRF평균회복시간차이균무통계학의의(P＞0.05).결론 IRF시AML환자접수대제량아당포감공고화료후제시골수조혈공능회복적조기지표,대우평고료효구유중요림상의의.
Objective To investigate the clinical significance of peripheral blood parameters including immature reticulocyte fraction (IRF) in monitoring the hematopoietic recovery of patients with acute myeloid leukemia aftcr receiving consolidation chemotherapy with high dose cytarabine (HDAC).Methods The peripheral blood parameters,including absolute neutrophil (ANC) and platelet (Plt) counts as well as IRF,were measured by Sysmex XE-2100 automated hematology analyzer before and after consolidation chemotherapy with HDAC in 30 patients with acute myeloid leukemia.These peripheral blood parameters were further statistically analyzed and compared.Results Following consolidation chemotherapy,the median time to recovery for ANC,Plt and IRF was (9.2±2.5) days,(11.3±3.7) days and (5.0±2.6) days,respectively.In comparison with ANC and Plt recovery,IRF showed significantly early recovery (P ＜ 0.05).Additionally,ANC raised preceding Plt recovery (P ＜ 0.05).However,the median recovery time of ANC,Plt and IRF showed little difference among these patients further subgrouped according to FAB and risk based classification (P ＞ 0.05).Conclusion IRF is an early indicator for the hematopoietic recovery of patients with acute myeloid leukemia following consolidation chemotherapy with HDAC,which could provide important clinical information to evaluate therapeutic efficacy.
