CAJ | 학술논문

目的探讨间变性大细胞淋巴瘤(ALCL)患者外周血中内皮祖细胞(EPC)的数量变化在疾病预后中的意义.方法采用流式细胞术检测30例ALCL患者以及对照健康体检者10名外周血中EPC的数量,进行绝对计数,并与临床预后指标国际预后指数(IPI)评分以及间变淋巴瘤细胞激酶(ALK)资料进行对比.结果 ALCL患者治疗前外周血EPC绝对计数为(15.530±28.659)个/μl,与对照组的(0.515±0.294)个/μl相比较,差异有统计学意义(P＜ 0.001).根据IPI评分标准,把ALCL患者分为低危组(0～1分)、中危组(2～3分)、高危组(4～5分)三组,外周血EPC绝对计数分别为(6.508±7.356)个/μl、(16.830±24.273)个/μl、(21.521±36.057)个/μl,在低危组与中危组、高危组中差异有统计学意义(P＜ 0.01);中危组与高危组中差异无统计学意义(P＞0.05);外周血EPC绝对计数在ALK+与ALK-ALCL患者中分别为(8.367±9.609)个/μl和(22.541±20.845)个/μl,差异有统计学意义(P＜0.01).ALCL患者外周血EPC绝对计数分为＜20个/μl组与≥20个/μl组,两组间在60周内生存曲线差异有统计学意义.结论外周血EPC绝对计数与ALCL临床病情进展程度可能有一定的关系,有可能成为评价患者治疗效果及预后的指标之一.
목적 탐토간변성대세포림파류(ALCL)환자외주혈중내피조세포(EPC)적수량변화재질병예후중적의의.방법 채용류식세포술검측30례ALCL환자이급대조건강체검자10명외주혈중EPC적수량,진행절대계수,병여림상예후지표국제예후지수(IPI)평분이급간변림파류세포격매(ALK)자료진행대비.결과 ALCL환자치료전외주혈EPC절대계수위(15.530±28.659)개/μl,여대조조적(0.515±0.294)개/μl상비교,차이유통계학의의(P＜ 0.001).근거IPI평분표준,파ALCL환자분위저위조(0～1분)、중위조(2～3분)、고위조(4～5분)삼조,외주혈EPC절대계수분별위(6.508±7.356)개/μl、(16.830±24.273)개/μl、(21.521±36.057)개/μl,재저위조여중위조、고위조중차이유통계학의의(P＜ 0.01);중위조여고위조중차이무통계학의의(P＞0.05);외주혈EPC절대계수재ALK+여ALK-ALCL환자중분별위(8.367±9.609)개/μl화(22.541±20.845)개/μl,차이유통계학의의(P＜0.01).ALCL환자외주혈EPC절대계수분위＜20개/μl조여≥20개/μl조,량조간재60주내생존곡선차이유통계학의의.결론 외주혈EPC절대계수여ALCL림상병정진전정도가능유일정적관계,유가능성위평개환자치료효과급예후적지표지일.
Objective To check the changes of endothelial progenitor cell (EPC) number of patients with anaplastic large cell lymphoma (ALCL) in the peripheral blood,investigate their clinical significance.Methods The number of EPC in blood was determined by FCM method in 30 patients with ALCL and 10 healthy cases as the control group.Results The number of EPC in the peripheral blood of patients with ALCL before treatment was significantly higher (15.530±28.659/μl) than that in control group (0.515 ±0.294/μl,P ＜ 0.001).The number of EPC of ALCL patients in the high-risk groups (21.521±36.057/μl) and the middle-risk groups (16.830±24.273/μ1) differently increaasd than that of the low-risk group (6.508±7.356/μl,P ＜ 0.01),but between the high-risk groups and the middle-risk groups there was no significant value (P ＞ 0.05).There were significant difference between the number of EPC of ALK+-ALCL (8.367±9.609/μl) and ALK-ALCL (22.541± 20.845/μl) patients (P ＜ 0.01).The survive curve before 60 weeks had significant difference between groups of ＞20/μl and ＜20/μl of EPC.Conclusion EPC may be correlated with progression of the disease in a certain degree.Dynamic observation with the level of EPC may be used to evaluate the treatment outcomes and act as a prognostic marker for ALCL.