CAJ | 학술논문

目的分析急性髓系白血病(AML)患者骨髓FMS样酪氨酸激酶3基因内部串联重复(FLT3／ITD)突变情况.方法采用聚合酶链反应方法检测96例初发AML患者FLT3／ITD突变,分析FLT3／ITD阳性患者的临床特征.结果 96例AML患者中FLT3／ITD突变18例(18.8％).其中M22例,M3 11例,M42例,M53例.FLT3／ITD阳性AML患者初发时外周血白细胞计数中位数为18.0×109／L(3.6× 109～ 137.6×109/L),FLT3／ITD阴性AML患者为6.3×109/L(4.5×109 ～ 113.0×109/L),两组比较差异有统计学意义(t=3.04,P＜0.05).FLT3／ITD阳性者随访16例,中位随访时间10个月(6～ 15个月),13例处于第1次完全缓解.诱导缓解率为81.3％(13／16).结论 FLT3／ITD是AML患者常见的基因突变,FLT3／ITD阳性患者白细胞计数较高.
목적 분석급성수계백혈병(AML)환자골수FMS양락안산격매3기인내부천련중복(FLT3／ITD)돌변정황.방법 채용취합매련반응방법검측96례초발AML환자FLT3／ITD돌변,분석FLT3／ITD양성환자적림상특정.결과 96례AML환자중FLT3／ITD돌변18례(18.8％).기중M22례,M3 11례,M42례,M53례.FLT3／ITD양성AML환자초발시외주혈백세포계수중위수위18.0×109／L(3.6× 109～ 137.6×109/L),FLT3／ITD음성AML환자위6.3×109/L(4.5×109 ～ 113.0×109/L),량조비교차이유통계학의의(t=3.04,P＜0.05).FLT3／ITD양성자수방16례,중위수방시간10개월(6～ 15개월),13례처우제1차완전완해.유도완해솔위81.3％(13／16).결론 FLT3／ITD시AML환자상견적기인돌변,FLT3／ITD양성환자백세포계수교고.
Objective To analyze the mutations of FMS-like tyrosine kinase 3 internal tandem duplication (FLT3/ITD) in bone marrow cells of patients with newly-diagnosed acute myeloid leukemia (AML).Methods The mutations of FLT3/ITD in 96 AML cases were detected by polymerase chain reaction (PCR)and the clinical features of FLT3/ITD positive patients were analyzed.Results FLT3/ITD mutations were identified in 18 patients (18.8 ％),2 cases were M2,11 cases were M3,2 cases were M4,3 cases were Ms.Patients with FLT3/ITD mutations presented higher initial white blood cell count than that of patients without FLT3/ITD mutations [18.0×109/L (3.6×109-137.6×109/L) vs 6.3×109/L (4.5×109-113.0×109/L),t =3.04,P ＜ 0.05].Out of FLT3/ITD positive patients,13/16 (81.3 ％) obtained complete remission and 13 patients remained in first remission in a median follow-up of 10 months(6-15 months).Conclusion The mutations of FLT3/ITD are frequently identified in newly-diagnosed AML patients,patients with FLT3/ITD mutations present high white blood cell count.