CAJ | 학술논문

目的探讨血管免疫母细胞性T细胞淋巴瘤患者的EB病毒感染情况及其临床病理学意义.方法回顾性分析2008年1月至2011年12月经常规外检及会诊确诊的血管免疫母细胞性T细胞淋巴瘤62例,进行常规形态学和免疫学表型分析,采用原位杂交方法检测EB病毒编码小RNA(EBV-EBER)的表达情况,并随访患者.结果 62例血管免疫母细胞性T细胞淋巴瘤患者中,EBV-EBER阳性者26例(42％).EBV-EBER表达与患者年龄大于60岁以及治疗反应密切相关(P=0.025、0.049),而与患者的总体生存时间、临床B症状及Ann Arbor分期无关(均P＞0.05).结论血管免疫母细胞性T细胞淋巴瘤患者EB病毒感染不影响总体生存时间,但影响患者对治疗的反应.
목적 탐토혈관면역모세포성T세포림파류환자적EB병독감염정황급기림상병이학의의.방법 회고성분석2008년1월지2011년12월경상규외검급회진학진적혈관면역모세포성T세포림파류62례,진행상규형태학화면역학표형분석,채용원위잡교방법검측EB병독편마소RNA(EBV-EBER)적표체정황,병수방환자.결과 62례혈관면역모세포성T세포림파류환자중,EBV-EBER양성자26례(42％).EBV-EBER표체여환자년령대우60세이급치료반응밀절상관(P=0.025、0.049),이여환자적총체생존시간、림상B증상급Ann Arbor분기무관(균P＞0.05).결론 혈관면역모세포성T세포림파류환자EB병독감염불영향총체생존시간,단영향환자대치료적반응.
Objective To investigate the EB virus (EBV) infection and its clinical significance in angioimmunoblastic T-cell lymphoma(AITCL).Methods 62 patients diagnosed as AITCL between 2008 Jan and 2011 Dec were retrospective analyzed.All cases were re-confirmed and classified with the histology and immunology according to 2008 WHO Classification.In situ hybridization of EBV encoded RNA (EBV-EBER) was performed.Clinical characteristics and follow-up data of patients were collected.Results 42 ％ (26/62) AITCL cases were EBER-positive.EBV infection was found to be significant correlation with age over 60 years and poor response to therapy (P =0.025,P =0.049,respectively).However,EBV infection had no relationship with the overall survival,the presence of B symptom and the Ann Arbor stage.Conclusion In AITCL,EBV infection seems not to be associated with the overall survival,B symptom and Ann Arbor stage,but it may have impacts on theraputic response.