CAJ | 학술논문

肿瘤病毒病因的研究已经历了一个世纪,近半个世纪以来确立了7种人类肿瘤病毒,初步阐明了人类肿瘤病毒致病机制的复杂性及其特殊规律.人类基因组测序结果表明约8％的基因由人类内源性反转录病毒(HERV)组成,成年人T细胞白血病病毒(HTLV)与成年人T细胞白血病、动物的外源性和内源性反转录病毒与肿瘤及恶性疾病关系的证实,引发了对HERV与人类肿瘤发生、发展关系的关注和研究.文章介绍了白血病和实体瘤中HERV的表达及其与病情的关系.HERV与肿瘤的关系可能是肿瘤病毒学的一个重要方面,不仅有重要的理论意义,还有潜在的应用前景.
종류병독병인적연구이경력료일개세기,근반개세기이래학립료7충인류종류병독,초보천명료인류종류병독치병궤제적복잡성급기특수규률.인류기인조측서결과표명약8％적기인유인류내원성반전록병독(HERV)조성,성년인T세포백혈병병독(HTLV)여성년인T세포백혈병、동물적외원성화내원성반전록병독여종류급악성질병관계적증실,인발료대HERV여인류종류발생、발전관계적관주화연구.문장개소료백혈병화실체류중HERV적표체급기여병정적관계.HERV여종류적관계가능시종류병독학적일개중요방면,불부유중요적이론의의,환유잠재적응용전경.
Viral etiology of tumor has been studied for a century.Seven human tumor viruses were identified over the past half century.The complexity and regularity of the pathogenic mechanisms of human tumor viruses have been elucidated preliminarily.Human genome sequencing indicated that 8 ％ of human genes were composed of human endogenous retroviruses (HERVs).Owing to the findings that adult T-cell leukemia virus (HTLV) can cause human adult T-cell leukemia and animal exogenous and HERVs can induce tumors and malignant diseases,the relationship between HERVs and human tumors has attracted much attention receutly.Here this article discusses the association of the expression of HERVs with leukemia and solid tumors progression,which may be an important aspect of tumor virology.