白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2014年
4期
208-212
,共5页
王聪%袁长吉%何华%白鸥
王聰%袁長吉%何華%白鷗
왕총%원장길%하화%백구
淋巴瘤,大B细胞,弥漫型%原发部位%临床特点%病理分型%预后
淋巴瘤,大B細胞,瀰漫型%原髮部位%臨床特點%病理分型%預後
림파류,대B세포,미만형%원발부위%림상특점%병리분형%예후
Lymphoma,large B-cell,diffuse%Primary site%Clinical characteristic%Pathological subtype%Prognosis
目的 比较原发结外与结内弥漫大B细胞淋巴瘤(DLBCL)患者的临床病理特点及预后方面的差异.方法 回顾分析2007年1月至2012年12月134例DLBCL患者的临床病理特征及治疗疗效.结果 DLBCL 134例,占同期收治非霍奇金淋巴瘤(NHL)的52.14％(134/257),结外DLBCL共93例占总体DLBCL的69.4％.结外DLBCL分期为Ⅲ～Ⅳ期者占55.9％(52/93),结内DLBCL中Ⅲ～Ⅳ期者占75.6％(31/41),差异有统计学意义(P=0.035).结外DLBCL中乳酸脱氢酶升高者占33.3％(31/93),而结内DLBCL中升高者占58.5％(24/41),差异有统计学意义(P=0.008).其他临床特征如出现B症状、大肿块、骨髓浸润、红细胞沉降率升高的比例及美国东部肿瘤协作组(ECOG)评分、国际预后指数(IPI)评分差异均无统计学意义(均P＞0.05).结外与结内DLBCL生发中心及非生发中心起源出现的比例差异无统计学意义(P=0.623).结外与结内DLBCL的3年总生存率分别为73.2％、55.2％,3年疾病无进展生存率分别为46.3％、44.1％,差异均无统计学意义(P值分别为0.065、0.748).结论 原发结外DLBCL的发病率较高,与结内DLBCL相比其临床分期较早,肿瘤负荷较低,但两者的免疫表型、分化特征及预后无明显差异.
目的 比較原髮結外與結內瀰漫大B細胞淋巴瘤(DLBCL)患者的臨床病理特點及預後方麵的差異.方法 迴顧分析2007年1月至2012年12月134例DLBCL患者的臨床病理特徵及治療療效.結果 DLBCL 134例,佔同期收治非霍奇金淋巴瘤(NHL)的52.14％(134/257),結外DLBCL共93例佔總體DLBCL的69.4％.結外DLBCL分期為Ⅲ～Ⅳ期者佔55.9％(52/93),結內DLBCL中Ⅲ～Ⅳ期者佔75.6％(31/41),差異有統計學意義(P=0.035).結外DLBCL中乳痠脫氫酶升高者佔33.3％(31/93),而結內DLBCL中升高者佔58.5％(24/41),差異有統計學意義(P=0.008).其他臨床特徵如齣現B癥狀、大腫塊、骨髓浸潤、紅細胞沉降率升高的比例及美國東部腫瘤協作組(ECOG)評分、國際預後指數(IPI)評分差異均無統計學意義(均P＞0.05).結外與結內DLBCL生髮中心及非生髮中心起源齣現的比例差異無統計學意義(P=0.623).結外與結內DLBCL的3年總生存率分彆為73.2％、55.2％,3年疾病無進展生存率分彆為46.3％、44.1％,差異均無統計學意義(P值分彆為0.065、0.748).結論 原髮結外DLBCL的髮病率較高,與結內DLBCL相比其臨床分期較早,腫瘤負荷較低,但兩者的免疫錶型、分化特徵及預後無明顯差異.
목적 비교원발결외여결내미만대B세포림파류(DLBCL)환자적림상병리특점급예후방면적차이.방법 회고분석2007년1월지2012년12월134례DLBCL환자적림상병리특정급치료료효.결과 DLBCL 134례,점동기수치비곽기금림파류(NHL)적52.14％(134/257),결외DLBCL공93례점총체DLBCL적69.4％.결외DLBCL분기위Ⅲ～Ⅳ기자점55.9％(52/93),결내DLBCL중Ⅲ～Ⅳ기자점75.6％(31/41),차이유통계학의의(P=0.035).결외DLBCL중유산탈경매승고자점33.3％(31/93),이결내DLBCL중승고자점58.5％(24/41),차이유통계학의의(P=0.008).기타림상특정여출현B증상、대종괴、골수침윤、홍세포침강솔승고적비례급미국동부종류협작조(ECOG)평분、국제예후지수(IPI)평분차이균무통계학의의(균P＞0.05).결외여결내DLBCL생발중심급비생발중심기원출현적비례차이무통계학의의(P=0.623).결외여결내DLBCL적3년총생존솔분별위73.2％、55.2％,3년질병무진전생존솔분별위46.3％、44.1％,차이균무통계학의의(P치분별위0.065、0.748).결론 원발결외DLBCL적발병솔교고,여결내DLBCL상비기림상분기교조,종류부하교저,단량자적면역표형、분화특정급예후무명현차이.
Objective To evaluate the difference between nodal and extra-nodal diffuse large B-cell lymphoma (DLBCL) in clinical-pathological feature and prognosis.Methods The clinical data of 134 cases of DLBCL patients were reviewed and analyzed.Results The DLBCL patients accounted for 52.14 ％ (134/257) of non-Hodgkin lymphoma of the same period and the extra-nodal DLBCL patients accounted for 69.4 ％.The proportion of stage Ⅲ/Ⅳ disease in extra-nodal DLBCL and nodal DLBCL were 55.9 ％ (52/93) and 75.6 ％(31/41),respectively.Elevated LDH was reported in 33.3 ％ (31/93) of extra-nodal DLBCL and 58.5 ％ (24/41)of nodal DLBCL Other clinical characteristics such as B symptoms,bulky disease,elevated ESR,ECOG scores and IPI scores were not significantly different between these two groups (all P ＞ 0.05).No difference in the frequency of GCB and non-GCB subtypes was observed between extra-nodal and nodal DLBCL (P =0.623).The 3-year overall survival rates and 3-year progression free survival rates for extra-nodal and nodal DLBCL were 73.2 ％,55.2 ％ (P =0.065) and 46.3 ％,44.1％ (P =0.748).Conclusions The morbidity of extranodal DLBCL is high.Primary extra-nodal DLBCL patients present early-stage disease and normal LDH more frequently than the nodal DLBCL,while no significant difference in the frequency of pathological subtypes and 3-year OS and PFS is observed between these two groups.
