CAJ | 학술논문

目的探讨伴有t(16;21) (p11;q22)急性髓系白血病(AML)的临床及实验室检查特征.方法对2例伴t(16;21)(p11;q22) AML患者分别进行骨髓形态学瑞特-吉姆萨染色、细胞化学染色、免疫学表型检测、常见基因筛查及遗传学检查,分析其临床及实验室检查的异同点,并复习相关文献.结果例1 FAB形态学分型为AML-M4,其遗传学改变为:46,XY,t(16;21)(p11;q22) [16]/47,XY,t(16;21)(p11;q22),+21[4];例2为AML-M1,遗传学改变为46,XX,t(16;21)(p11;q22) [20].2例患者原始细胞均高表达CD56,均可见原始细胞吞噬自身血细胞现象.2例患者均于发病2年内死亡.结论伴t(16;21)(p11;q22) AML有其独特的形态学、免疫表型、遗传学异常和临床表现,预后差,造血干细胞移植可能为其首选的治疗方法.
목적 탐토반유t(16;21) (p11;q22)급성수계백혈병(AML)적림상급실험실검사특정.방법 대2례반t(16;21)(p11;q22) AML환자분별진행골수형태학서특-길모살염색、세포화학염색、면역학표형검측、상견기인사사급유전학검사,분석기림상급실험실검사적이동점,병복습상관문헌.결과 례1 FAB형태학분형위AML-M4,기유전학개변위:46,XY,t(16;21)(p11;q22) [16]/47,XY,t(16;21)(p11;q22),+21[4];례2위AML-M1,유전학개변위46,XX,t(16;21)(p11;q22) [20].2례환자원시세포균고표체CD56,균가견원시세포탄서자신혈세포현상.2례환자균우발병2년내사망.결론 반t(16;21)(p11;q22) AML유기독특적형태학、면역표형、유전학이상화림상표현,예후차,조혈간세포이식가능위기수선적치료방법.
Objective To investigate the clinical and laboratory characteristics of acute myeloid leukemia (AML) with t (16;21)(p11;q22) translocation.Methods Two patients diagnosed by morphology,cytochemical stain,immunology,cytogenetics and genetic testing.Similarities and differences of clinical characteristics and laboratory examination were analysed,along with a review of the literatures.Results According to the FAB classification,one patient was M4 and the other one was M1.The cytogenetic aberrations were 46,XY,t(16;21)(p11;q22)[16]/47,XY,t(16;21)(p11;q22),+21[4] of ease 1 and 46,XX,t(16;21)(p11;q22)[20] of case 2.Cytophagocytosis and CD56 antigen expression were found in both cases.The prognosis was poor in both cases.Conclusions AML with t(16;21)(p11;q22) is a specific type,which has unusual characteristics of morphology,immunology,cytogenetics,clinical feature.The prognosis of the patients is poor,so stem-cell transplantation maybe the only and the first choice of treatment.