CAJ | 학술논문

肿瘤作为体内产生的新生物可在有限的时空内发生微进化.肿瘤细胞克隆在遗传变异和表观遗传学机制改变的调控下呈线性或分枝进化,多数临床患者的肿瘤呈嵌合式分枝进化,导致肿瘤的异质性,影响其发展,是临床难治和易于复发的生物学基础,已引起研究者的关注.文章以急性髓系白血病(AML)和骨髓增生异常综合征(MDS)等为例介绍肿瘤微进化的历程和线性/分枝进化的概念,并对肿瘤微进化研究的一些问题和方向进行了讨论.
종류작위체내산생적신생물가재유한적시공내발생미진화.종류세포극륭재유전변이화표관유전학궤제개변적조공하정선성혹분지진화,다수림상환자적종류정감합식분지진화,도치종류적이질성,영향기발전,시림상난치화역우복발적생물학기출,이인기연구자적관주.문장이급성수계백혈병(AML)화골수증생이상종합정(MDS)등위례개소종류미진화적역정화선성/분지진화적개념,병대종류미진화연구적일사문제화방향진행료토론.
As novel organisms,tumors undergo microevolution in limited time and space in vivo.Due to genetic mutations and epigenetic mechanisms,tumor cell clones undergo linear or branching evolution.In most clinic patients,tumors develop through branching evolution pathways,causing tumor heterogeneity and affecting tumor progression.Microevolution is the biological basis for the refractoriness and recurrence of tumors and has been paid attention in research and clinic recently.In this paper,acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are used as examples to demonstrate tumor microevolution and the concept of linear and branching evolution.Questions and perspective in the field of tumor microevolution research are also discussed.