CAJ | 학술논문

原发纵隔大B细胞淋巴瘤(PMBCL)是一种特殊类型的B细胞淋巴瘤,推测来源于胸腺髓质B细胞,占所有弥漫大B细胞淋巴瘤(DLBCL)的6％～10％,具有特殊的病理特征、免疫表型和基因异常,需要与经典型霍奇金淋巴瘤和其他结性DLBCL亚型鉴别.文章就PMBCL的病理学特征、分子生物学改变、治疗、预后及正电子发射型计算机断层扫描显像(PET)在评估初始治疗反应中的作用进行介绍.
원발종격대B세포림파류(PMBCL)시일충특수류형적B세포림파류,추측래원우흉선수질B세포,점소유미만대B세포림파류(DLBCL)적6％～10％,구유특수적병리특정、면역표형화기인이상,수요여경전형곽기금림파류화기타결성DLBCL아형감별.문장취PMBCL적병이학특정、분자생물학개변、치료、예후급정전자발사형계산궤단층소묘현상(PET)재평고초시치료반응중적작용진행개소.
Primary mediastinal large B-cell lymphoma (PMBCL) is a unique type of B-cell lymphoma probably arising from a putative thymic medulla B cell.It constitutes 6 ％-10 ％ of all diffuse large B-cell lymphomas (DLBCL),with special pathologic features,immunophenotype and genetic abnormlities,and need to be identified with classical Hodgkin lymphoma and other types of DLBCL.In this review,the pathological features,molecular biological changes,treatment,prognosis and treatment of PET in the evaluation of the initial reaction in PMBCL were summarized.