CAJ | 학술논문

目的分析肠球菌属的分布特点及多重耐药性,为临床控制和预防多重耐药菌感染提供有效依据.方法采用法国生物梅里埃ATB自动鉴定仪进行病原菌鉴定和药敏试验,并对其分布特点及药敏结果进行统计分析.结果 142株肠球菌属中以粪肠球菌为主,102株(71.8％),屎肠球菌次之,36株(25.4％)标本来源以尿液为主,64株(45.1％),其次为胆汁,27株(19.0％)主要分布在肾内科,38株(26.8％),其次为泌尿烧伤科,34株(23.9％)未检出耐万古霉素和替考拉宁菌株;屎肠球菌对喹奴普汀/达福普汀、氯霉素、四环素的耐药率(8.3％～19.4％)明显低于粪肠球菌(32.4％～ 91.2％),对高浓度氨基糖苷类和其它多数抗生素的耐药率(38.9％～91.7％)明显高于粪肠球菌(11.8％～65.7％),差异有显著性(P＜0.05).结论肠球菌种间耐药差异明显,屎肠球菌多重耐药程度高于粪肠球菌,因此临床分离的肠球菌应准确鉴定到种,才能更好地指导临床合理选用抗菌药物.
목적 분석장구균속적분포특점급다중내약성,위림상공제화예방다중내약균감염제공유효의거.방법 채용법국생물매리애ATB자동감정의진행병원균감정화약민시험,병대기분포특점급약민결과진행통계분석.결과 142주장구균속중이분장구균위주,102주(71.8％),시장구균차지,36주(25.4％)표본래원이뇨액위주,64주(45.1％),기차위담즙,27주(19.0％)주요분포재신내과,38주(26.8％),기차위비뇨소상과,34주(23.9％)미검출내만고매소화체고랍저균주;시장구균대규노보정/체복보정、록매소、사배소적내약솔(8.3％～19.4％)명현저우분장구균(32.4％～ 91.2％),대고농도안기당감류화기타다수항생소적내약솔(38.9％～91.7％)명현고우분장구균(11.8％～65.7％),차이유현저성(P＜0.05).결론 장구균충간내약차이명현,시장구균다중내약정도고우분장구균,인차림상분리적장구균응준학감정도충,재능경호지지도림상합리선용항균약물.
Objective To provide an effective basis for clinical control and prevention of multi-drug-resistant bacterial infections by analyzing the distribution features and multi-drug-resistant of enterococcus.Methods The French Merieux ATB Expression Automated Analysis System was used for bacterial identification and antimricrobial susceptibility test,distribution characteristics and antimicrobial susceptibility results were statistically analyzed.Results The main strains of 142 enterococcus was enterococcus faecalis 102(71.8％),the second was E.faecium 36(25.4％).Specimen source were found mainly from urine 64(45.1％),then bile 27(19.0％),and was mainly distributed in the Nephrology unit 38 (26.8％),the second as Urologic Surgery 34(23.9％).There was no drug-resistance had been spotted for Enterococcus to Vancomycin and Teicoplanin.The resistance rates of E.faecium to Quinupristin/Dalfopristin,Chloramphenieol and Tetracycline were significantly lower than those of E.faecalis,but contrary to high concentrations aminoglycosides of and most of other antibiotics.There was statistical significant difference between the two srtains(P＜ 0.05).Conclusions The drug-resistance of strains of enterococcus differed greatly.The multiple drug-resistant rate of E.faecium strains to most common drugs test is higher than that of E.faecalis.In order to better conduct clinical therapy of choosing antibiotic reasonably,we should be identified to the species of Enterococcus.