国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
3期
313-316
,共4页
原发性高血压%微量白蛋白尿%转化生长因子β1%肾动脉阻力指数
原髮性高血壓%微量白蛋白尿%轉化生長因子β1%腎動脈阻力指數
원발성고혈압%미량백단백뇨%전화생장인자β1%신동맥조력지수
Primary hypertension%Microalbuminuria%Transforming growth factor beta-1%Renal arterial resistive index
目的 观察原发性高血压合并微量白蛋白尿患者血清转化生长因子β1(TGF-β1)及肾动脉阻力指数(RRI)的变化及相关性.方法 选取原发性高血压病患者92例,根据尿白蛋白肌酐比值(UACR)分为正常白蛋白尿组(UACR＜ 30 mg/g)、微量白蛋白尿组(30 mg/g≤UACR＜ 300 mg/g)和临床蛋白尿组(UACR≥300 mg/g),并设立健康对照组.采用ELISA方法测定血清TGF-β1,彩色多谱勒超声测定肾动脉阻力指数,同时测定相关临床指标.结果 正常白蛋白尿组TGF-β1为(8.9±2.9) μg/L,RRI为(0.59±0.06),微量白蛋白尿组和临床蛋白尿组血清TGF-β 1水平分别为(11.4±4.9)μg/L、(15.5±5.6) μg/L,RRI分别为(0.64±0.06)、(0.70±0.05),均明显高于正常白蛋白尿组(P＜0.01).血清TGF-β 1水平和RRI呈正相关(r=0.416,P＜ 0.05),微量白蛋白尿水平、TGFβ1、RRI均与eGFR呈负相关(r值分别为-0.352、-0.394、-0.419,P＜ 0.05).结论 高血压合并微量白蛋白尿的患者血清TGF-β1水平和肾动脉阻力指数均升高,两者均与eGFR呈负相关.
目的 觀察原髮性高血壓閤併微量白蛋白尿患者血清轉化生長因子β1(TGF-β1)及腎動脈阻力指數(RRI)的變化及相關性.方法 選取原髮性高血壓病患者92例,根據尿白蛋白肌酐比值(UACR)分為正常白蛋白尿組(UACR＜ 30 mg/g)、微量白蛋白尿組(30 mg/g≤UACR＜ 300 mg/g)和臨床蛋白尿組(UACR≥300 mg/g),併設立健康對照組.採用ELISA方法測定血清TGF-β1,綵色多譜勒超聲測定腎動脈阻力指數,同時測定相關臨床指標.結果 正常白蛋白尿組TGF-β1為(8.9±2.9) μg/L,RRI為(0.59±0.06),微量白蛋白尿組和臨床蛋白尿組血清TGF-β 1水平分彆為(11.4±4.9)μg/L、(15.5±5.6) μg/L,RRI分彆為(0.64±0.06)、(0.70±0.05),均明顯高于正常白蛋白尿組(P＜0.01).血清TGF-β 1水平和RRI呈正相關(r=0.416,P＜ 0.05),微量白蛋白尿水平、TGFβ1、RRI均與eGFR呈負相關(r值分彆為-0.352、-0.394、-0.419,P＜ 0.05).結論 高血壓閤併微量白蛋白尿的患者血清TGF-β1水平和腎動脈阻力指數均升高,兩者均與eGFR呈負相關.
목적 관찰원발성고혈압합병미량백단백뇨환자혈청전화생장인자β1(TGF-β1)급신동맥조력지수(RRI)적변화급상관성.방법 선취원발성고혈압병환자92례,근거뇨백단백기항비치(UACR)분위정상백단백뇨조(UACR＜ 30 mg/g)、미량백단백뇨조(30 mg/g≤UACR＜ 300 mg/g)화림상단백뇨조(UACR≥300 mg/g),병설립건강대조조.채용ELISA방법측정혈청TGF-β1,채색다보륵초성측정신동맥조력지수,동시측정상관림상지표.결과 정상백단백뇨조TGF-β1위(8.9±2.9) μg/L,RRI위(0.59±0.06),미량백단백뇨조화림상단백뇨조혈청TGF-β 1수평분별위(11.4±4.9)μg/L、(15.5±5.6) μg/L,RRI분별위(0.64±0.06)、(0.70±0.05),균명현고우정상백단백뇨조(P＜0.01).혈청TGF-β 1수평화RRI정정상관(r=0.416,P＜ 0.05),미량백단백뇨수평、TGFβ1、RRI균여eGFR정부상관(r치분별위-0.352、-0.394、-0.419,P＜ 0.05).결론 고혈압합병미량백단백뇨적환자혈청TGF-β1수평화신동맥조력지수균승고,량자균여eGFR정부상관.
Objective To investigate the changes of serum transforming growth factor hera-1 (TGF-β 1) and renal arterial resistive index (RRI) in patients with hypertension complicated by microalbuminuria.The correlation between TGF-β 1 and RRI was analyzed.Methods 92 patients with primary hypertension were assigned to normal albuminuria group (UACR ＜ 30 mg/g),microalbuminuria group (300mg/g＞UACR ≥ 30 mg/g),and clinical proteinuria group (UACR ≥ 300 mg/g) according to the level of UACR.The conrtrol group with health subjects was established.Serum TGF-β 1 levels,RRI,and related clinical indicators were measured.Results Serum TGF-β 1 levels and RRI were significantly higher in both microalbuminuria group and clinical proteinuria group than in normal albuminuria group (P ＜ 0.01).Serum TGF-β 1level was positively correlated with RRI level; levels of microalbuminuria,TGF-β 1 and RRI were all negatively correlated with estimated glomerular filtration rate (eGFR).Conclusions Levels of serum transforming growth factor beta-1 and renal arterial resistive index are higher in patients with hypertension and microalbuminuria.Both TGF-β 1 and RRI have a negative correlation with estimated glomerular fiiltration rate.
