国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
8期
1074-1077
,共4页
罗明乾%冼翠华%钟业娟%梁锦云%轩慧杰%石晓峰
囉明乾%冼翠華%鐘業娟%樑錦雲%軒慧傑%石曉峰
라명건%승취화%종업연%량금운%헌혜걸%석효봉
血液透析%N末端脑钠肽前体%干体重
血液透析%N末耑腦鈉肽前體%榦體重
혈액투석%N말단뇌납태전체%간체중
Hemodialysis%NT-proBNP%Dry weight
目的 研究维持性血透(maintenance heamodialysis,MHD)患者血清N末端B型钠尿肽原(NT-pro brain natriuretic peptide,NT-proBNP)水平与干体重的关系,寻找有效的评价干体重的方法.方法 分别测定18例干体重控制良好(干体重达标组)MHD患者和20例干体重控制不良MHD患者(干体重未达标组)血清NT-proBNP,测定干体重未达标组患者经过4周下调干体重治疗前后的血清NT-proBNP的水平,记录各患者临床、生化数据及心功能阶段分级(ACC/AHA).结果 所有MHD患者血清NT-proBNP水平高于临床诊断值3419.3(2368.7～5728.3)pg/ml.干体重达标组的血清NT-proBNP水平2872.4(1907.3～3655.9) pg/ml,干体重未达标组的血清NT-proBNP水平4568.4(3236.3～6530.4) pg/ml,两组数据比较有统计学意义(P＜0.01);干体重未达标组治疗前后血清NT-proBNP水平中位数(4568.4vs2569.0pg/ml)明显下降,有统计学意义(P＜0.01).结论 血清NT-proBNP水平能反映MHD的干体重,可作为干体重评估的简单、有效方法.
目的 研究維持性血透(maintenance heamodialysis,MHD)患者血清N末耑B型鈉尿肽原(NT-pro brain natriuretic peptide,NT-proBNP)水平與榦體重的關繫,尋找有效的評價榦體重的方法.方法 分彆測定18例榦體重控製良好(榦體重達標組)MHD患者和20例榦體重控製不良MHD患者(榦體重未達標組)血清NT-proBNP,測定榦體重未達標組患者經過4週下調榦體重治療前後的血清NT-proBNP的水平,記錄各患者臨床、生化數據及心功能階段分級(ACC/AHA).結果 所有MHD患者血清NT-proBNP水平高于臨床診斷值3419.3(2368.7～5728.3)pg/ml.榦體重達標組的血清NT-proBNP水平2872.4(1907.3～3655.9) pg/ml,榦體重未達標組的血清NT-proBNP水平4568.4(3236.3～6530.4) pg/ml,兩組數據比較有統計學意義(P＜0.01);榦體重未達標組治療前後血清NT-proBNP水平中位數(4568.4vs2569.0pg/ml)明顯下降,有統計學意義(P＜0.01).結論 血清NT-proBNP水平能反映MHD的榦體重,可作為榦體重評估的簡單、有效方法.
목적 연구유지성혈투(maintenance heamodialysis,MHD)환자혈청N말단B형납뇨태원(NT-pro brain natriuretic peptide,NT-proBNP)수평여간체중적관계,심조유효적평개간체중적방법.방법 분별측정18례간체중공제량호(간체중체표조)MHD환자화20례간체중공제불량MHD환자(간체중미체표조)혈청NT-proBNP,측정간체중미체표조환자경과4주하조간체중치료전후적혈청NT-proBNP적수평,기록각환자림상、생화수거급심공능계단분급(ACC/AHA).결과 소유MHD환자혈청NT-proBNP수평고우림상진단치3419.3(2368.7～5728.3)pg/ml.간체중체표조적혈청NT-proBNP수평2872.4(1907.3～3655.9) pg/ml,간체중미체표조적혈청NT-proBNP수평4568.4(3236.3～6530.4) pg/ml,량조수거비교유통계학의의(P＜0.01);간체중미체표조치료전후혈청NT-proBNP수평중위수(4568.4vs2569.0pg/ml)명현하강,유통계학의의(P＜0.01).결론 혈청NT-proBNP수평능반영MHD적간체중,가작위간체중평고적간단、유효방법.
Objective To investigate the relationship between plasma NT-pro brain natriuretic peptide (NT-proBNP) levels and dry weight in patients in maintenance hemodialysis (MHD) and to evaluate the clinical value of NT-proBNP in the assessment of dry weight.Methods NT-proBNP level was determined in 18 cases of MHD patients with well-controlled dry weight and 20 eases of MHD patients with bad-controlled dry weight,while the latter would be checked once again after the weight was down-regulated to dry weight in 4 weeks.Results The average level of NT-proBNP was 3419.3(2368.7～5728.3) pg/ml which was higher than normal.Plasma NT-proBNP levels were significantly lower in patients with well-controlled dry weight than those patients with bad-controlled dry weight (2872.4 vs 4568.4) pg/ml,and there was very significant difference in plasma NT-proBNP levels between pre and post treatment of down-regulation to dry weight in patients with bad-controlled dry weight (4568.4 vs 2569.0) pg/ml.Conclusions Plasma NT-proBNP can be a good marker for the evaluation of dry weight in MHD patients.
