CAJ | 학술논문

目的对比FOLFOX4常规方案与时辰化疗方案治疗晚期原发性肝癌的近期疗效及毒副反应.方法选取2011年1月至2012年6月经病理和(或)组织细胞学确诊为晚期原发性肝癌患者60例,随机分为时辰化疗组和常规化疗组各30例,观察并比较两组临床疗效及不良反应发生情况.结果常规化疗组部分缓解5例,病灶稳定9例,疾病进展16例；时辰化疗组部分缓解13例,病灶稳定9例,疾病进展8例.不良反应以骨髓抑制、消化道不良反应和肝肾功能损伤为主,多为1～2级.时辰化疗组生活质量的改善优于常规化疗组.结论 FOLFOX4时辰化疗方案治疗晚期原发性肝癌优于常规方案,可进一步提高疗效,降低毒副作用,具有临床推广价值.
목적 대비FOLFOX4상규방안여시신화료방안치료만기원발성간암적근기료효급독부반응.방법 선취2011년1월지2012년6월경병리화(혹)조직세포학학진위만기원발성간암환자60례,수궤분위시신화료조화상규화료조각30례,관찰병비교량조림상료효급불량반응발생정황.결과 상규화료조부분완해5례,병조은정9례,질병진전16례；시신화료조부분완해13례,병조은정9례,질병진전8례.불량반응이골수억제、소화도불량반응화간신공능손상위주,다위1～2급.시신화료조생활질량적개선우우상규화료조.결론 FOLFOX4시신화료방안치료만기원발성간암우우상규방안,가진일보제고료효,강저독부작용,구유림상추엄개치.
Objective To study the clinical effects and toxicity between chrono-chemotherapy of FOLFOX4 and conventional chemotherapy of in the treatment of advanced primary hepatocellular cancer.Methods Selecting 60 cases from Jan 2011 to Jun 2012 in our hospital.All of the cases were diagnosed as advanced primary hepatocellular cancer by pathological examination or histiocytes and then they were randomly divided into the control group (n=30,conventional chemotherapy of FOLFOX4) and the experimental group (n=30,chrono-chemotherapy of FOLFOX4),follow-up was conducted and we observed curative effect and complications of two groups,and compared the efficacy and safety.Results The control group had 5 cases of partial remission,16 cases of disease progression and others were stable,the experimental group had 13 cases of partial remission,8 cases of disease progression,9 stable cases.The adverse reactions were mainly bone marrow suppression,gastrointestinal reaction and liver/kidney damage,with majority of them in grade 1 or 2.The quality of life improvement of the experimental group was better than that of control group,showing statistical significant difference.Conclusion Chrono-chemotherapy of FOLFOX4 in treating advanced primary hepatocellular cancer,compared with that of conventional method,has better effect,lower adverse reaction and it is a preferable chemotherapy for clinical promotion.