CAJ | 학술논문

目的分析汕头市住院耐多药肺结核患者结核分枝杆菌对二线抗结核药物的耐药情况,为制定治疗方案提供依据.方法分析2010年8月至2012年7月135例住院耐多药肺结核患者结核分枝杆菌对Am、Lfx和Pto的药物敏感性试验结果,观察初治组和复治组对二线抗结核药物的耐药率.结果初治组耐Lfx 10.0％、耐Am 10.0％、耐Pto 6.7％,复治组耐Lfx 23.8％、耐Am 17.1％、耐Pto 4.8％;初治组未发现广泛耐药患者,复治组中广泛耐药患者13例(12.4％).结论对于耐多药肺结核患者,进行二线抗结核药物敏感试验,有利于耐多药肺结核个体化方案的制定.
목적 분석산두시주원내다약폐결핵환자결핵분지간균대이선항결핵약물적내약정황,위제정치료방안제공의거.방법 분석2010년8월지2012년7월135례주원내다약폐결핵환자결핵분지간균대Am、Lfx화Pto적약물민감성시험결과,관찰초치조화복치조대이선항결핵약물적내약솔.결과 초치조내Lfx 10.0％、내Am 10.0％、내Pto 6.7％,복치조내Lfx 23.8％、내Am 17.1％、내Pto 4.8％;초치조미발현엄범내약환자,복치조중엄범내약환자13례(12.4％).결론 대우내다약폐결핵환자,진행이선항결핵약물민감시험,유리우내다약폐결핵개체화방안적제정.
Objective To analyze resistant situation to second-line anti-TB drugs of mycobacterium tuberculosis among inpatients with MDR-TB in the Third People's Hospital of Shantou,and provide the evidence for making the treatment regimens.Methods The analysis was conducted on drug susceptibility testing to Am,Lfx and Pto of mycobacterium tuberculosis among 135 inpatients with MDR-TB from Aug 1 st,2010 to Jul 31st,2012.The second-line drug resistance rate of new treatment group and re-treatment group were observed.Results The secondline drug resistance rate of Lfx,Am and Pro in new treatment group were 10.0％,10.0％ and 6.7％ respectively,23.8％,17.1％ and 4.8％ respectively in re-treatment group.There were no XDR-TB patients in new treatment group,and 13 XDR-TB patients (accounting for 12.4％) were found in re-treatment group.Conclusion The second-line anti-TB drug susceptibility testing will help us to make the individual treatment regimens for the MDR-TB patients.