CAJ | 학술논문

目的探讨血清穿孔素(PFN)抗体、粒溶素(GNLY)抗体和颗粒蛋白酶A(GrA)抗体的表达水平与肺结核的相关性.方法应用双抗原夹心ELISA法检测24例肺结核患者和12例其它呼吸疾病患者血清PFN抗体、GNLY抗体和GrA抗体,描述性分析肺结核患者和其它呼吸疾病患者的三种血清抗体水平,并对二者进行比较分析.结果肺结核患者血清PFN抗体、GNLY抗体和GrA抗体水平分别为29～463、7～156、11～164ng/L,(-x±s)分别为(107±107)、(34±41)、(36±34)ng/L;其它呼吸疾病患者血清PFN抗体、GNLY抗体和GrA抗体水平分别为31～347、0～117、11～87 ng/L,(-x±s)分别为(103±99)、(24±31)、(27±21)ng/L.血清PFN抗体、GNLY抗体和GrA抗体水平差异无统计学意义(P＜0.05).结论血清PFN抗体、GNLY抗体和GrA抗体水平与肺结核无特异性相关.
목적 탐토혈청천공소(PFN)항체、립용소(GNLY)항체화과립단백매A(GrA)항체적표체수평여폐결핵적상관성.방법 응용쌍항원협심ELISA법검측24례폐결핵환자화12례기타호흡질병환자혈청PFN항체、GNLY항체화GrA항체,묘술성분석폐결핵환자화기타호흡질병환자적삼충혈청항체수평,병대이자진행비교분석.결과 폐결핵환자혈청PFN항체、GNLY항체화GrA항체수평분별위29～463、7～156、11～164ng/L,(-x±s)분별위(107±107)、(34±41)、(36±34)ng/L;기타호흡질병환자혈청PFN항체、GNLY항체화GrA항체수평분별위31～347、0～117、11～87 ng/L,(-x±s)분별위(103±99)、(24±31)、(27±21)ng/L.혈청PFN항체、GNLY항체화GrA항체수평차이무통계학의의(P＜0.05).결론 혈청PFN항체、GNLY항체화GrA항체수평여폐결핵무특이성상관.
Objective To investigate the relationship between the levels of anti-perforin and antigranulysin and anti-granzyme A in serum with pulmonary tuberculosis.Methods Anti-perforin,antigranulysin and anti-granzyme A in serum samples of 24 patients with pulmonary tuberculosis patients and 12 patients with other respiratory disease were determined by ELISA of double antigen sandwich.The descriptive analysis of three kinds of serum antibody levels and comparison analysis of population mean of two group cases were performed.Results The levels of anti-perforin and anti-granulysin and anti-granzyme A in serum of patients with pulmonary tuberculosis were in the range of 29-463,7-156,11-164 ng/L respectively,while their level range were 31-347,0-117,11-87 ng/L in serum of patients with other respiratory disease respectively.As to population mean of two group cases,(-x ± s) of anti-perforin and anti-granulysin and anti-granzyme A in serum of patients with pulmonary tuberculosis were (107 ± 107),(34 ± 41),(36 ± 34) ng/L respectively,while they were (103 ± 99),(24 ± 31),(27 ± 21) ng/L in serum of patients with other respiratory disease respectively.Conclusion There is no specific correlation between the levels of anti-perforin and anti-granulysin and antigranzyme A in serum with pulmonary tuberculosis.