国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
18期
2912-2915
,共4页
陈广峰%阳宇%刘艳辉%钟纬经%梁浩和
陳廣峰%暘宇%劉豔輝%鐘緯經%樑浩和
진엄봉%양우%류염휘%종위경%량호화
Rosai-Dorfman病%鼻腔%组织细胞增多症%免疫组织化学%鉴别诊断
Rosai-Dorfman病%鼻腔%組織細胞增多癥%免疫組織化學%鑒彆診斷
Rosai-Dorfman병%비강%조직세포증다증%면역조직화학%감별진단
Rosai-Dorfman disease%Nasal cavity%Histiocytosis%Immunohistochemistry%Differential diagnosis
目的 探讨鼻腔结外Rosai-Dorfman病(RDD)的临床表现、病理特征及鉴别诊断.方法 对2例鼻腔结外RDD采用光镜及免疫组化、特殊染色结合临床资料及文献复习,对鼻腔结外RDD进行临床病理分析.结果 鼻腔结外RDD形态学有不同程度的纤维组织增生和以浆细胞为主的混合炎细胞浸润,胞质内含有淋巴细胞和浆细胞的大多角形组织细胞数量多少不一,呈簇状或散在分布.结论 鼻腔结外RDD较为少见,诊断有一定难度,形态学易与鼻硬结病、Langerhans细胞组织细胞增生症、肉芽肿性炎症、纤维组织细胞瘤等相混淆,需要免疫组化和特殊染色加以鉴别.
目的 探討鼻腔結外Rosai-Dorfman病(RDD)的臨床錶現、病理特徵及鑒彆診斷.方法 對2例鼻腔結外RDD採用光鏡及免疫組化、特殊染色結閤臨床資料及文獻複習,對鼻腔結外RDD進行臨床病理分析.結果 鼻腔結外RDD形態學有不同程度的纖維組織增生和以漿細胞為主的混閤炎細胞浸潤,胞質內含有淋巴細胞和漿細胞的大多角形組織細胞數量多少不一,呈簇狀或散在分佈.結論 鼻腔結外RDD較為少見,診斷有一定難度,形態學易與鼻硬結病、Langerhans細胞組織細胞增生癥、肉芽腫性炎癥、纖維組織細胞瘤等相混淆,需要免疫組化和特殊染色加以鑒彆.
목적 탐토비강결외Rosai-Dorfman병(RDD)적림상표현、병리특정급감별진단.방법 대2례비강결외RDD채용광경급면역조화、특수염색결합림상자료급문헌복습,대비강결외RDD진행림상병리분석.결과 비강결외RDD형태학유불동정도적섬유조직증생화이장세포위주적혼합염세포침윤,포질내함유림파세포화장세포적대다각형조직세포수량다소불일,정족상혹산재분포.결론 비강결외RDD교위소견,진단유일정난도,형태학역여비경결병、Langerhans세포조직세포증생증、육아종성염증、섬유조직세포류등상혼효,수요면역조화화특수염색가이감별.
Objective To study the clinical manifestations,pathological features and differential diagnosis of extranodal Rosai-Dorfman disease (RDD) in nasal cavity.Methods The clinical,pathologic,immunohistochemical and special staining features of 2 cases of RDD were evaluated and related literatures were reviewed.Results Extranodal RDD in nasal cavity and various degrees of stromal fibrosis were seen association with mixed inflammatory cells (especially plasma cells).The large polygonal histiocytes varied in number and were distributed in clusters or patches.Conclusion Extranodal RDD of nasal cavity is relatively rare and pathologic diagnosis may be difficult.It can easily mimic rhinoscleroma,hyperplasia of langerhans cells,granulomatous inflammation and fibrous tumors.Immunohistochemical and histochemical study is helpful in the differential diagnosis.