国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
19期
2945-2948
,共4页
何聚莲%唐盈%林佩萱%屈艳霞%江帆%陈桂兰%何桂儿
何聚蓮%唐盈%林珮萱%屈豔霞%江帆%陳桂蘭%何桂兒
하취련%당영%림패훤%굴염하%강범%진계란%하계인
HPV感染%鳞状上皮癌抗原%宫颈癌
HPV感染%鱗狀上皮癌抗原%宮頸癌
HPV감염%린상상피암항원%궁경암
HPV infection%SCC-Ag%Cervical cancer
目的 探讨HPV-DNA检测和SCC-Ag检测在宫颈癌筛查中的应用价值,探求更准确的宫颈癌初筛指标.方法 选择经病理确诊的517例CIN患者,63例宫颈癌患者以及20例健康对照者进行宫颈分泌物HPV-DNA检测和血清SCC-Ag(鳞状上皮癌抗原)检测,并对实验结果进行单个指标和联合检测分析.结果 以SCC-Ag≥1.5 ng/ml为阳性,CIN组阳性率为4.45％,宫颈癌组阳性率为66.67％,差异有统计学意义;CIN组HPV-DNA检测阳性率为4.26％,宫颈癌组HPV-DNA阳性率为96.83％,差异有统计学意义.HPV-DNA诊断宫颈癌的敏感度为96.83％,特异度为95.90％,检测准确性为96.00％; SCC-Ag诊断宫颈癌的敏感度为66.67％,特异度为95.72％,检测准确性为92.67％;联合检测检出阳性58例,诊断宫颈癌的敏感度为87.30％,特异度为99.44％,准确性为98.17％.结论 HPV-DAN阳性者联合SCC-Ag检测可提高诊断的准确性,HPV-DNA检测和SCC-Ag检测联合应用对宫颈癌的诊断具有重要的临床意义.
目的 探討HPV-DNA檢測和SCC-Ag檢測在宮頸癌篩查中的應用價值,探求更準確的宮頸癌初篩指標.方法 選擇經病理確診的517例CIN患者,63例宮頸癌患者以及20例健康對照者進行宮頸分泌物HPV-DNA檢測和血清SCC-Ag(鱗狀上皮癌抗原)檢測,併對實驗結果進行單箇指標和聯閤檢測分析.結果 以SCC-Ag≥1.5 ng/ml為暘性,CIN組暘性率為4.45％,宮頸癌組暘性率為66.67％,差異有統計學意義;CIN組HPV-DNA檢測暘性率為4.26％,宮頸癌組HPV-DNA暘性率為96.83％,差異有統計學意義.HPV-DNA診斷宮頸癌的敏感度為96.83％,特異度為95.90％,檢測準確性為96.00％; SCC-Ag診斷宮頸癌的敏感度為66.67％,特異度為95.72％,檢測準確性為92.67％;聯閤檢測檢齣暘性58例,診斷宮頸癌的敏感度為87.30％,特異度為99.44％,準確性為98.17％.結論 HPV-DAN暘性者聯閤SCC-Ag檢測可提高診斷的準確性,HPV-DNA檢測和SCC-Ag檢測聯閤應用對宮頸癌的診斷具有重要的臨床意義.
목적 탐토HPV-DNA검측화SCC-Ag검측재궁경암사사중적응용개치,탐구경준학적궁경암초사지표.방법 선택경병리학진적517례CIN환자,63례궁경암환자이급20례건강대조자진행궁경분비물HPV-DNA검측화혈청SCC-Ag(린상상피암항원)검측,병대실험결과진행단개지표화연합검측분석.결과 이SCC-Ag≥1.5 ng/ml위양성,CIN조양성솔위4.45％,궁경암조양성솔위66.67％,차이유통계학의의;CIN조HPV-DNA검측양성솔위4.26％,궁경암조HPV-DNA양성솔위96.83％,차이유통계학의의.HPV-DNA진단궁경암적민감도위96.83％,특이도위95.90％,검측준학성위96.00％; SCC-Ag진단궁경암적민감도위66.67％,특이도위95.72％,검측준학성위92.67％;연합검측검출양성58례,진단궁경암적민감도위87.30％,특이도위99.44％,준학성위98.17％.결론 HPV-DAN양성자연합SCC-Ag검측가제고진단적준학성,HPV-DNA검측화SCC-Ag검측연합응용대궁경암적진단구유중요적림상의의.
Objective To study the application value of squamous cell carcinoma antigen(SCCAg) and HPV genotyping detection in diagnosis of cervical cancer.Method SCC-Ag and HPV were detected in 517 cases of CIN,63 cases of cervical cancer and 20 cases of healthy people.Results It took SCCAg ≥ 1.5 ng/ml as the cut-off.The positive rate in CIN group was 4.45％,while that in cervical cancer group was 66.67％.The positive rate of HPV-DNA in CIN group was 4.26％,while that in cervical cancer group was 96.83％.The sensitivity,specificity and accuracy rate of HPV-DNA were 96.83％,95.90％ and 96.00％; those of SCC-Ag were 66.67％,95.72％ and 92.67％; those of joint detection were 87.30％,99.44％ and 98.17％.Conclusions SCC-Ag can improve the accuracy rate of cervical cancer in HPV-DNA positive cases.The combination of SCC-Ag and HPV-DNA has important clinical significance in diagnosis of cervical cancer.
