国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
20期
3134-3137
,共4页
早孕期%唐氏综合征%妊娠相关血浆蛋白A(PAPP-A)%游离β-人绒毛膜促性腺激素(Fβ-HCG)%超声%血清学
早孕期%唐氏綜閤徵%妊娠相關血漿蛋白A(PAPP-A)%遊離β-人絨毛膜促性腺激素(Fβ-HCG)%超聲%血清學
조잉기%당씨종합정%임신상관혈장단백A(PAPP-A)%유리β-인융모막촉성선격소(Fβ-HCG)%초성%혈청학
Early pregnancy%Down syndrome%Pregnancy-associated plasma protein A (PAPP-A)%Free beta-human chorionic gonadotropin (F β-HCG)%Ultrasound%Serological
目的 探讨孕早期超声与血清学联合筛查对诊断唐氏综合征的价值.方法 回顾性分析2004年8月至2012年8月来我院门诊的2522例9～ 14周孕产妇的临床资料,采用时间分辨荧光免疫分析法检测孕妇血清中妊娠相关血浆蛋白A(PAPP-A)和游离β-人绒毛膜促性腺激素(Fβ-HCG),联合超声测定胎儿颈部透明膜厚度(NT).结果 2522例孕妇中,血清学检查阳性率4.3％,检出率66.7％；NT检查阳性率1.0％,检出率66.7％；两则结合阳性率4.5％,检出率100％.血清学联合彩色超声NT检查能提高检测率.血清学联合彩色超声NT检查阳性例数113例,其中异常染色体核型共14例,4例为DS核型,10例其他异常染色体核型.113例唐氏综合征筛查高风险孕妇不良结局44例,占38.9％ (44/113),2409例筛查低风险孕妇不良结局总数201例,占8.1％(201/2409),两组不良结局比较,差异有统计学意义(x2=115.19,P＜0.01).结论 PAPP-A、Fβ-HCG联合超声测量胎儿颈部NT筛查,不仅可提高孕妇孕早期DS检出率,而且对孕 妇的妊娠结局有一定指导意义.
目的 探討孕早期超聲與血清學聯閤篩查對診斷唐氏綜閤徵的價值.方法 迴顧性分析2004年8月至2012年8月來我院門診的2522例9～ 14週孕產婦的臨床資料,採用時間分辨熒光免疫分析法檢測孕婦血清中妊娠相關血漿蛋白A(PAPP-A)和遊離β-人絨毛膜促性腺激素(Fβ-HCG),聯閤超聲測定胎兒頸部透明膜厚度(NT).結果 2522例孕婦中,血清學檢查暘性率4.3％,檢齣率66.7％；NT檢查暘性率1.0％,檢齣率66.7％；兩則結閤暘性率4.5％,檢齣率100％.血清學聯閤綵色超聲NT檢查能提高檢測率.血清學聯閤綵色超聲NT檢查暘性例數113例,其中異常染色體覈型共14例,4例為DS覈型,10例其他異常染色體覈型.113例唐氏綜閤徵篩查高風險孕婦不良結跼44例,佔38.9％ (44/113),2409例篩查低風險孕婦不良結跼總數201例,佔8.1％(201/2409),兩組不良結跼比較,差異有統計學意義(x2=115.19,P＜0.01).結論 PAPP-A、Fβ-HCG聯閤超聲測量胎兒頸部NT篩查,不僅可提高孕婦孕早期DS檢齣率,而且對孕 婦的妊娠結跼有一定指導意義.
목적 탐토잉조기초성여혈청학연합사사대진단당씨종합정적개치.방법 회고성분석2004년8월지2012년8월래아원문진적2522례9～ 14주잉산부적림상자료,채용시간분변형광면역분석법검측잉부혈청중임신상관혈장단백A(PAPP-A)화유리β-인융모막촉성선격소(Fβ-HCG),연합초성측정태인경부투명막후도(NT).결과 2522례잉부중,혈청학검사양성솔4.3％,검출솔66.7％；NT검사양성솔1.0％,검출솔66.7％；량칙결합양성솔4.5％,검출솔100％.혈청학연합채색초성NT검사능제고검측솔.혈청학연합채색초성NT검사양성례수113례,기중이상염색체핵형공14례,4례위DS핵형,10례기타이상염색체핵형.113례당씨종합정사사고풍험잉부불량결국44례,점38.9％ (44/113),2409례사사저풍험잉부불량결국총수201례,점8.1％(201/2409),량조불량결국비교,차이유통계학의의(x2=115.19,P＜0.01).결론 PAPP-A、Fβ-HCG연합초성측량태인경부NT사사,불부가제고잉부잉조기DS검출솔,이차대잉 부적임신결국유일정지도의의.
Objective To investigate the value of ultrasound and serological screening for early diagnosis of down syndrome in early pregnancy.Methods Clinical data of 2522 pregnant women with 9 to 14 weeks of pregnancy were retrospectively analyzed from August 2004 to August 2012 in our hospital.Maternal serum pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (F β hCG) were detected by time-resolved fluorescence immunoassay,and the film thickness of nuchal translucency (NT) was detected by ultrasound.Results Among 2522 pregnant women,serology positive rate was 4.3％,the detection rate was 66.7％.NT-positive rate was 1.0％,the detection rate was 66.7％.Positive rate for combination of two methods was 4.5％,the detection rate was 100％.Serological combined with color Doppler ultrasound NT examination could improve the detection rate.113 positive cases by serology and color ultrasonic NT check,there were 14 cases for abnormal karyotype,4 cases for DS karyotype,10 cases for other abnormal chromosome karyotypes.About 113 cases for down syndrome screening high-risk,there were 44 cases for adverse outcomes,accounting for 38.9％ (44/113),about 2409 cases for screening low-risk,there were 201 cases for adverse outcomes,accounting for 8.1％ (201/2409),there was statistical significant difference (x 2=115.19,P＜0.01).Conclusion PAPP-A,F β-HCG and ultrasonic measurement fetal neck NT can not only improve the DS detection rate in pregnant women in early pregnancy,but also has guiding significance for pregnancy outcomes.
