国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
21期
3298-3301
,共4页
行为神经评分%鼠神经生长因子%智能发育商%缺氧缺血性脑病
行為神經評分%鼠神經生長因子%智能髮育商%缺氧缺血性腦病
행위신경평분%서신경생장인자%지능발육상%결양결혈성뇌병
Behavioral neurological assessment%Mouse nerve growth factor%Intelligent Quotient%Hypoxic-ischemic encephalopathy
目的 探讨鼠神经生长因子(mNGF)在减少缺氧缺血性脑病新生儿(HIE)血清NSE释放及保护神经功能的干预效果.方法 抽选89例中重度HIE患者,采用分层随机法分为对照组(n=44例)和观察组(n=45例),两组均予以常规综合治疗,对照组在此基础上加胞二磷胆碱治疗,观察组加用mNGF治疗,比较两组患儿治疗后症状改善时间、行为神经评分(NBNA)、血清中NSE等生化指标的差异,治疗后随访1年,比较两组患儿智能发育商(DQ)的变化.结果 观察组患儿意识、肌张力、反射恢复及惊厥改善时间明显短于对照组(P＜0.05).两组患儿治疗第1 ～3 d(28.44±2.36 vs.28.42±2.32)NBNA评分比较差异无统计学意义(P＞0.05)；观察组第4～6d(32.78±2.33 vs.30.01±2.35)、第7～ 10 d(37.23±2.01 vs.33.13±2.09)患儿NBNA评分明显高于对照组(P＜0.05).治疗前两组患儿血清S-100B、NSE比较差异无统计学意义(P＞0.05)；治疗3d及7d后观察组患儿血清NSE分别为(17.31±2.11)、(12.39±1.77),均明显低于对照组(20.83±2.31)、(14.93±1.83),P＜0.05.治疗后随访1年,观察组患儿的DQ正常率(86.7％)明显高于对照组(61.4％),P＜ 0.05.结论 mNGF治疗新生儿HIE,可明显减少患儿血清NSE的释放,保护神经功能,提高患儿智能发育商的正常率.
目的 探討鼠神經生長因子(mNGF)在減少缺氧缺血性腦病新生兒(HIE)血清NSE釋放及保護神經功能的榦預效果.方法 抽選89例中重度HIE患者,採用分層隨機法分為對照組(n=44例)和觀察組(n=45例),兩組均予以常規綜閤治療,對照組在此基礎上加胞二燐膽堿治療,觀察組加用mNGF治療,比較兩組患兒治療後癥狀改善時間、行為神經評分(NBNA)、血清中NSE等生化指標的差異,治療後隨訪1年,比較兩組患兒智能髮育商(DQ)的變化.結果 觀察組患兒意識、肌張力、反射恢複及驚厥改善時間明顯短于對照組(P＜0.05).兩組患兒治療第1 ～3 d(28.44±2.36 vs.28.42±2.32)NBNA評分比較差異無統計學意義(P＞0.05)；觀察組第4～6d(32.78±2.33 vs.30.01±2.35)、第7～ 10 d(37.23±2.01 vs.33.13±2.09)患兒NBNA評分明顯高于對照組(P＜0.05).治療前兩組患兒血清S-100B、NSE比較差異無統計學意義(P＞0.05)；治療3d及7d後觀察組患兒血清NSE分彆為(17.31±2.11)、(12.39±1.77),均明顯低于對照組(20.83±2.31)、(14.93±1.83),P＜0.05.治療後隨訪1年,觀察組患兒的DQ正常率(86.7％)明顯高于對照組(61.4％),P＜ 0.05.結論 mNGF治療新生兒HIE,可明顯減少患兒血清NSE的釋放,保護神經功能,提高患兒智能髮育商的正常率.
목적 탐토서신경생장인자(mNGF)재감소결양결혈성뇌병신생인(HIE)혈청NSE석방급보호신경공능적간예효과.방법 추선89례중중도HIE환자,채용분층수궤법분위대조조(n=44례)화관찰조(n=45례),량조균여이상규종합치료,대조조재차기출상가포이린담감치료,관찰조가용mNGF치료,비교량조환인치료후증상개선시간、행위신경평분(NBNA)、혈청중NSE등생화지표적차이,치료후수방1년,비교량조환인지능발육상(DQ)적변화.결과 관찰조환인의식、기장력、반사회복급량궐개선시간명현단우대조조(P＜0.05).량조환인치료제1 ～3 d(28.44±2.36 vs.28.42±2.32)NBNA평분비교차이무통계학의의(P＞0.05)；관찰조제4～6d(32.78±2.33 vs.30.01±2.35)、제7～ 10 d(37.23±2.01 vs.33.13±2.09)환인NBNA평분명현고우대조조(P＜0.05).치료전량조환인혈청S-100B、NSE비교차이무통계학의의(P＞0.05)；치료3d급7d후관찰조환인혈청NSE분별위(17.31±2.11)、(12.39±1.77),균명현저우대조조(20.83±2.31)、(14.93±1.83),P＜0.05.치료후수방1년,관찰조환인적DQ정상솔(86.7％)명현고우대조조(61.4％),P＜ 0.05.결론 mNGF치료신생인HIE,가명현감소환인혈청NSE적석방,보호신경공능,제고환인지능발육상적정상솔.
Objective To explore the intervention effect of mouse nerve growth factor on reducing the release of serum NSE and neurological protection in the children with neonatal hypoxic-ischemic encephalopathy (HIE).Method 89 patients with moderate to severe HIE was chosen,and then were randomly divided into a control group (n=44) and an observation group (n=45) with stratified method.Both groups were treated with conventional therapy; in addition,the control group administered brain protein citicoline,and the observation group took mNGF.The time of symptoms improvement,behavioral neurological score (NBNA),serum NSE and so on were compared between the 2 groups.After 1 years' follow-up,smart developmental quotient (DQ) of the two groups were compared.Results The improvement times of awareness,muscle tone,reflex recovery,and seizures were significantly shorter in the observation group than in the control group (P ＜ 0.05).Day 1-3 of the treatment,there was no statistical difference in NBNA score (28.44 ± 2.36 vs.28.42 ± 2.32) between the observation group and the control group(P ＞ 0.05); but day 4-6 and 7-10,there were statistical differences (32.78 ± 2.33 vs.30.01 ± 2.35,37.23 ± 2.01 vs.33.13 ± 2.09,P ＜ 0.05).Before the treatment,there were no statistical differences in serum S-100B and NSE between the 2 groups (P ＞ 0.05);3 and 7 days after the treatment,the serum S-100B and NSE were (17.31 ± 2.11) and (12.39 ± 1.77) were in the observation group and were (20.83 ± 2.31),(14.93 ± 1.83) in the control group,respectively,with statistical differences(P ＜ 0.05).After the 1-year follow-up,DQ normal rate was statistically higher in the observation group than in the control group (86.7％ vs.61.4％,P ＜ 0.05).Conclusion mNGF for neonatal hypoxic-ischemic encephalopathy can significantly reduce serum NSE release,protect nerve function,and improve the intellectual development of children's normal rate.
