CAJ | 학술논문

目的探讨血清降钙素原(Procalcitonin,PCT)水平在诊治急性上呼吸道感染患者中的临床意义.方法选取2013年1月至2013年11月江门市中心医院急诊科诊治的急性上呼吸道感染患者199例,随机分为2组:常规组98例和PCT组101例.在相同常规诊疗的基础上,常规组按照抗生素指南进行治疗,PCT组加测血清PCT水平,根据PCT水平指导抗生素治疗.观察2组的临床疗效、退热时间、抗生素使用率、疗程和抗生素不良反应发生率;比较2组的抗生素费用和总费用.采用t检验和x2检验进行统计学分析.结果 PCT组患者的抗生素使用率(51.49％)、抗生素疗程(3.01±0.77)d、抗生素的费用(159.98±188.17)元、总费用(880.42±349.16)元均低于常规组的90.82％、(4.37±0.62)d、(228.71±147.85)元、(975.22±403.02)元,差异有统计学意义;PCT组的临床有效率89.11％、退热时间(3.29±1.45)d与常规组临床有效率92.86％、退热时间(3.40±1.69)d相比,差异无统计学意义.结论急性上呼吸道感染患者首诊时进行血清PCT水平检测对合理使用抗生素有重要指导意义.
목적 탐토혈청강개소원(Procalcitonin,PCT)수평재진치급성상호흡도감염환자중적림상의의.방법 선취2013년1월지2013년11월강문시중심의원급진과진치적급성상호흡도감염환자199례,수궤분위2조:상규조98례화PCT조101례.재상동상규진료적기출상,상규조안조항생소지남진행치료,PCT조가측혈청PCT수평,근거PCT수평지도항생소치료.관찰2조적림상료효、퇴열시간、항생소사용솔、료정화항생소불량반응발생솔;비교2조적항생소비용화총비용.채용t검험화x2검험진행통계학분석.결과 PCT조환자적항생소사용솔(51.49％)、항생소료정(3.01±0.77)d、항생소적비용(159.98±188.17)원、총비용(880.42±349.16)원균저우상규조적90.82％、(4.37±0.62)d、(228.71±147.85)원、(975.22±403.02)원,차이유통계학의의;PCT조적림상유효솔89.11％、퇴열시간(3.29±1.45)d여상규조림상유효솔92.86％、퇴열시간(3.40±1.69)d상비,차이무통계학의의.결론 급성상호흡도감염환자수진시진행혈청PCT수평검측대합리사용항생소유중요지도의의.
Objective To explore the clinical significance of serum procalcitonin (PCT) level in the diagnosis and treatment of patients with acute upper respiratory tract infection.Methods 199 patients with acute upper respiratory tract infection treated at Jiangmen central hospital from Jan 2013 to Nov 2013 were divided into a conventional group(n=101) and a PCT group(n=98).The conventional group was treated with antibiotic according to the antibiotic guidance,while the PCT group with antibiotic according to serum PCT levels.Both groups were also treated with routine therapy.The clinical efficacies,defervescence times,ratio of antibiotics usage,courses of antibiotics treatment and incidences of adverse reaction in both groups were observed.The cost of antibiotics and total cost were compared between the two groups.Results The ratio of antibiotics usage,course of antibiotics treatment,cost of antibiotics,and total costs were 51.49％,(3.01 ± 0.77) d,(159.98 ± 188.17) yuan,and (880.42 ± 349.16) yuan in the PCT group and were 90.82％,(4.37 ± 0.62) d,(228.71 ± 147.85) yuan,and (975.22 ± 403.02) yuan in the conventional group,with statistical differences (P ＜ 0.05).There were no significant differences in clinical efficacy and defervescence time between the PCT group and conventional group(89.1 1％ vs.92.86％,[3.29 ± 1.45] d vs.[3.40 ± 1.69] d).Conclusions Serum PCT level is useful for guiding antibiotics usage in the patients with acute upper respiratory tract infection.