国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
14期
2214-2216
,共3页
抗室性心律失常药%有效性%安全性%药物经济学%成本-效果分析
抗室性心律失常藥%有效性%安全性%藥物經濟學%成本-效果分析
항실성심률실상약%유효성%안전성%약물경제학%성본-효과분석
Anti-ventricular arrhythmia drugs%Efficacy%Safety%Pharmacoeconomics%Cost-effectiveness analysis
目的 对口服抗室性心律失常药物进行药物经济学评价,为合理选择抗室性心律失常药物治疗方案提供参考.方法 通过文献检索,汇总了10种抗室性心律失常药有效性、安全性的信息;以各种药物每月药费范围上限为成本,有效率为效果,进行成本-效果分析及敏感度分析.结果 抗室性心律失常药总有效率是78.71％,药物不良反应率为13.97％;成本-效果比较低的药物依次是美西律＜阿替洛尔＜普罗帕酮＜胺碘酮＜索他洛尔＜美托洛尔＜比索洛尔;成本-效果比较高的药物依次是莫雷西嗪＞稳心颗粒＞参松养心胶囊.药物不良反应率较低的药物依次是比索洛尔＜参松养心胶囊＜稳心颗粒＜阿替洛尔＜美托洛尔;药物不良反应率较高的药物依次是索他洛尔＞莫雷西嗪＞美西律＞胺碘酮＞普罗帕酮.结论 阿替洛尔、美托洛尔、比索洛尔属高效价廉安全的抗室性心律失常药,在药物经济学中鼓励使用高效低成本及安全的药物.
目的 對口服抗室性心律失常藥物進行藥物經濟學評價,為閤理選擇抗室性心律失常藥物治療方案提供參攷.方法 通過文獻檢索,彙總瞭10種抗室性心律失常藥有效性、安全性的信息;以各種藥物每月藥費範圍上限為成本,有效率為效果,進行成本-效果分析及敏感度分析.結果 抗室性心律失常藥總有效率是78.71％,藥物不良反應率為13.97％;成本-效果比較低的藥物依次是美西律＜阿替洛爾＜普囉帕酮＜胺碘酮＜索他洛爾＜美託洛爾＜比索洛爾;成本-效果比較高的藥物依次是莫雷西嗪＞穩心顆粒＞參鬆養心膠囊.藥物不良反應率較低的藥物依次是比索洛爾＜參鬆養心膠囊＜穩心顆粒＜阿替洛爾＜美託洛爾;藥物不良反應率較高的藥物依次是索他洛爾＞莫雷西嗪＞美西律＞胺碘酮＞普囉帕酮.結論 阿替洛爾、美託洛爾、比索洛爾屬高效價廉安全的抗室性心律失常藥,在藥物經濟學中鼓勵使用高效低成本及安全的藥物.
목적 대구복항실성심률실상약물진행약물경제학평개,위합리선택항실성심률실상약물치료방안제공삼고.방법 통과문헌검색,회총료10충항실성심률실상약유효성、안전성적신식;이각충약물매월약비범위상한위성본,유효솔위효과,진행성본-효과분석급민감도분석.결과 항실성심률실상약총유효솔시78.71％,약물불량반응솔위13.97％;성본-효과비교저적약물의차시미서률＜아체락이＜보라파동＜알전동＜색타락이＜미탁락이＜비색락이;성본-효과비교고적약물의차시막뢰서진＞은심과립＞삼송양심효낭.약물불량반응솔교저적약물의차시비색락이＜삼송양심효낭＜은심과립＜아체락이＜미탁락이;약물불량반응솔교고적약물의차시색타락이＞막뢰서진＞미서률＞알전동＞보라파동.결론 아체락이、미탁락이、비색락이속고효개렴안전적항실성심률실상약,재약물경제학중고려사용고효저성본급안전적약물.
Objective To evaluate the pharmacoeconomical outcome of anti-ventricular arrhythmia drugs,to provide reference for national selection of anti-ventricular arrhythmia drugs.Methods By searching literatures,collected the information of efficacy and safety of 10 kinds of anti-ventricular arrhythmia drugs; took the top limit of monthly expense as cost and efficiency as effectiveness to do cost-effectiveness analysis and sensitivity analysis.Results The total effective rate of anti-ventricular arrhythmia medicine was 78.71％,and drug adverse reaction rate was 13.97％.The low cost-effectiveness drugs were mexiletine ＜ atenolol ＜ propafenone ＜ amiodarone ＜ sotolol ＜ metoprolol ＜ bisoprolol; the high cost-effectiveness drugs were moracizine ＞ Wenxin grannle ＞ SRYX capsule; the low ADR rate drugs were bisoprolol ＜ SRYX capsule ＜ Wenxin grannle ＜ atenolol ＜ metoprolol; the high ADR rate drugs were sotolol ＞ moracizine ＞ mexiletine ＞ amiodarone ＞ propafenone.Conclusion Atenolol,metoprolol,bisoprolol belong to high efficient,safe and low cost medicine.In the drug economics we encourage to use high efficient,safe and low cost drugs.
