国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2013年
2期
55-60
,共6页
秦圆方%许可%祁贤%邓斐%潘玉宁%付建光%王慎骄%田华%单军
秦圓方%許可%祁賢%鄧斐%潘玉寧%付建光%王慎驕%田華%單軍
진원방%허가%기현%산비%반옥저%부건광%왕신교%전화%단군
冠状病毒%流感样病例%实时荧光定量PCR%流行特征
冠狀病毒%流感樣病例%實時熒光定量PCR%流行特徵
관상병독%류감양병례%실시형광정량PCR%류행특정
Coronavirus%Influenza-like illness%Real-time PCR%Epidemiologic feature
目的 分析2010年11月至2012年10月南京地区4个型别冠状病毒流行病学特征.方法 采集江苏省人民医院与南京医科大学第二附属医院流感样(influenza-like illness,ILI)病例咽拭子标本,并收集患者相关信息,利用RT-PCR方法进行检测,应用SPSS 17.0对数据进行统计分析.结果 1233例标本中,冠状病毒核酸阳性者共有115份(总阳性率9.33％),主要为229E型(36.52％,42/115)、OC43型(29.57％,34/115)与HKU1型(25.22％,29/115).2010-2012年不同年份间,冠状病毒229E型、HKU1型与NL63型阳性率有统计学差异(229E亚型:X2=18.072,P＜0.001；HKU1亚型:X2 =22.091,P＜0.001；NL63亚型:X2 =6.470,P=0.039).结论 南京地区冬季为冠状病毒流行高峰期,夏季为低谷期,春秋季小高峰趋势不明显.2010-2012年南京地区人呼吸道冠状病毒主要流行亚型为229E型、OC43型与HKU1型.不同年份冠状病毒主要流行亚型存在一定差异.
目的 分析2010年11月至2012年10月南京地區4箇型彆冠狀病毒流行病學特徵.方法 採集江囌省人民醫院與南京醫科大學第二附屬醫院流感樣(influenza-like illness,ILI)病例嚥拭子標本,併收集患者相關信息,利用RT-PCR方法進行檢測,應用SPSS 17.0對數據進行統計分析.結果 1233例標本中,冠狀病毒覈痠暘性者共有115份(總暘性率9.33％),主要為229E型(36.52％,42/115)、OC43型(29.57％,34/115)與HKU1型(25.22％,29/115).2010-2012年不同年份間,冠狀病毒229E型、HKU1型與NL63型暘性率有統計學差異(229E亞型:X2=18.072,P＜0.001；HKU1亞型:X2 =22.091,P＜0.001；NL63亞型:X2 =6.470,P=0.039).結論 南京地區鼕季為冠狀病毒流行高峰期,夏季為低穀期,春鞦季小高峰趨勢不明顯.2010-2012年南京地區人呼吸道冠狀病毒主要流行亞型為229E型、OC43型與HKU1型.不同年份冠狀病毒主要流行亞型存在一定差異.
목적 분석2010년11월지2012년10월남경지구4개형별관상병독류행병학특정.방법 채집강소성인민의원여남경의과대학제이부속의원류감양(influenza-like illness,ILI)병례인식자표본,병수집환자상관신식,이용RT-PCR방법진행검측,응용SPSS 17.0대수거진행통계분석.결과 1233례표본중,관상병독핵산양성자공유115빈(총양성솔9.33％),주요위229E형(36.52％,42/115)、OC43형(29.57％,34/115)여HKU1형(25.22％,29/115).2010-2012년불동년빈간,관상병독229E형、HKU1형여NL63형양성솔유통계학차이(229E아형:X2=18.072,P＜0.001；HKU1아형:X2 =22.091,P＜0.001；NL63아형:X2 =6.470,P=0.039).결론 남경지구동계위관상병독류행고봉기,하계위저곡기,춘추계소고봉추세불명현.2010-2012년남경지구인호흡도관상병독주요류행아형위229E형、OC43형여HKU1형.불동년빈관상병독주요류행아형존재일정차이.
Objective To study the epidemic characteristics of cases with all 4 subtypes of coronavirus diseases in Nanjing from November 2010 to October 2012.Methods In these two years,throat swabs and relevant information were collected from ILI (influenza-like illness) cases in Jiangsu Province Hospital and the Second Affiliated Hospital with Nanjing Medical University.All samples were detected using RT-PCR method.The results were analyzed with SPSS 17.0.Results Among all of the 1233 samples,coronavirus positive rate was 9.33％ (115/1233).Main prevalent subtypes were 229E (36.52％,42/115),OC43 (29.57％,34/115) and HKU1 (25.22％,29/115).There were statistics difference in the positive rates of 229E,HKU1 and NL 63 (229E subtype:X2 =18.072,P ＜0.001 ;HKU1 subtype:X2 =22.091,P ＜0.001 ;NL63 subtype:X2 =6.470,P =0.039) from 2010 to 2012.Conclusions In Nanjing,the subtypes of 229E,OC43 and HKU1 were epidemic from 2010 to 2012.The coronavirus positive rate peak occurs in winter,it is lower in summer.The trend is not obvious in spring and autumn.
