CAJ | 학술논문

目的探讨应用聚乙二醇干扰素联合利巴韦林抗病毒治疗慢性丙型肝炎,在治疗结束后,观察患者复发的影响因素及复发时间规律.方法对92例应用聚乙二醇干扰素联合利巴韦林抗病毒治疗的慢性丙型肝炎患者开展流行病学调查,通过病例对照研究,分析影响复发的因素.结果 92例患者中有81例获得持续病毒学应答,11例复发.其中持续应答组的快速病毒学应答率、完全早期病毒学应答率明显高于复发组,且差异有统计学意义(快速病毒学应答率P＜0.05；完全早期病毒学应答率P ＜0.001).11例复发者复发发生在停药后24周内,8例发生在12周内.结论聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎早出现病毒学应答,其复发率会越低.
목적 탐토응용취을이순간우소연합리파위림항병독치료만성병형간염,재치료결속후,관찰환자복발적영향인소급복발시간규률.방법 대92례응용취을이순간우소연합리파위림항병독치료적만성병형간염환자개전류행병학조사,통과병례대조연구,분석영향복발적인소.결과 92례환자중유81례획득지속병독학응답,11례복발.기중지속응답조적쾌속병독학응답솔、완전조기병독학응답솔명현고우복발조,차차이유통계학의의(쾌속병독학응답솔P＜0.05；완전조기병독학응답솔P ＜0.001).11례복발자복발발생재정약후24주내,8례발생재12주내.결론 취을이순간우소연합리파위림치료만성병형간염조출현병독학응답,기복발솔회월저.
Objective To evaluate the influencing factors of chronic hepatitis C relatpse treated with pegylated interferon alpha-2a and ribavirin in post-treatment,and study on relatpse time.Methods 92 chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin relapsed in post-treatment.A retrospective study was designed to analyze the influencing factors of chronic hepatitis C relatpse.Results 81 patients receives the sustained virological response(SVR),11 patients relapsed.The rapid virological response and complete early virological response of SVR patients were significantly higher than relapsed patients(P ＜0.05 ; P ＜0.001).11 relapsed patients occured within 24 weeks after stopped therapy,8 relapsed patients occured within 12 weeks.Conclusions The sooner of virus response to pgylated interferon alpha-2a plus ribavirin therapy,the lower of the relapse rate.