国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2013年
3期
123-127
,共5页
肾综合征出血热%彩色多普勒超声%血管性血友病因子
腎綜閤徵齣血熱%綵色多普勒超聲%血管性血友病因子
신종합정출혈열%채색다보륵초성%혈관성혈우병인자
Hemorrhagic fever with renal syndrome%Color Doppler ultrasonography%Von Willebrand factor
目的 研究肾综合征出血热(HFRS)患者肾脏彩色多普勒超声、血浆血管性血友病因子(vWF)、肝肾功能的变化及临床意义.方法 16例HFRS患者按病情分为轻、重两组,每组各8例,按病期进行肾脏二维及彩色多普勒超声检测,同时采血用酶联免疫吸附试验(ELISA)检测vWF,用自动生化仪检测血尿素氮(BUN)、肌酐(Cr)、丙氨酸氨基转移酶(ALT),用自动血细胞分析仪检测血小板参数；另取30名健康者作对照.结果 HFRS急性期左肾体积、段动脉(SRA)阻力指数(RI)及血浆vWF均显著升高,ALT、BUN也显著上升,在发热期轻、重二组相比有统计学差异(左肾体积:325.12 ±28.53v368.82 ±24.83,P＜0.05；左肾段动脉RI:0.59±0.02 v 0.66±0.03,P＜0.05；vWF:311.55 ±99.98μg/L v 356.36±54.21μg/L,P＜0.05)与BUN、ALT的变化基本一致,但血小板的变化则正相反.结论 HFRS患者肾损害各期的声像图与其临床病理变化密切相关,超声能动态观察病情各期肾损害的轻重,并能估计HFRS病情轻重,判断HFRS患者的临床治疗效果及其预后.肾脏超声检查具有准确、迅速、方便及无痛苦的优点.
目的 研究腎綜閤徵齣血熱(HFRS)患者腎髒綵色多普勒超聲、血漿血管性血友病因子(vWF)、肝腎功能的變化及臨床意義.方法 16例HFRS患者按病情分為輕、重兩組,每組各8例,按病期進行腎髒二維及綵色多普勒超聲檢測,同時採血用酶聯免疫吸附試驗(ELISA)檢測vWF,用自動生化儀檢測血尿素氮(BUN)、肌酐(Cr)、丙氨痠氨基轉移酶(ALT),用自動血細胞分析儀檢測血小闆參數；另取30名健康者作對照.結果 HFRS急性期左腎體積、段動脈(SRA)阻力指數(RI)及血漿vWF均顯著升高,ALT、BUN也顯著上升,在髮熱期輕、重二組相比有統計學差異(左腎體積:325.12 ±28.53v368.82 ±24.83,P＜0.05；左腎段動脈RI:0.59±0.02 v 0.66±0.03,P＜0.05；vWF:311.55 ±99.98μg/L v 356.36±54.21μg/L,P＜0.05)與BUN、ALT的變化基本一緻,但血小闆的變化則正相反.結論 HFRS患者腎損害各期的聲像圖與其臨床病理變化密切相關,超聲能動態觀察病情各期腎損害的輕重,併能估計HFRS病情輕重,判斷HFRS患者的臨床治療效果及其預後.腎髒超聲檢查具有準確、迅速、方便及無痛苦的優點.
목적 연구신종합정출혈열(HFRS)환자신장채색다보륵초성、혈장혈관성혈우병인자(vWF)、간신공능적변화급림상의의.방법 16례HFRS환자안병정분위경、중량조,매조각8례,안병기진행신장이유급채색다보륵초성검측,동시채혈용매련면역흡부시험(ELISA)검측vWF,용자동생화의검측혈뇨소담(BUN)、기항(Cr)、병안산안기전이매(ALT),용자동혈세포분석의검측혈소판삼수；령취30명건강자작대조.결과 HFRS급성기좌신체적、단동맥(SRA)조력지수(RI)급혈장vWF균현저승고,ALT、BUN야현저상승,재발열기경、중이조상비유통계학차이(좌신체적:325.12 ±28.53v368.82 ±24.83,P＜0.05；좌신단동맥RI:0.59±0.02 v 0.66±0.03,P＜0.05；vWF:311.55 ±99.98μg/L v 356.36±54.21μg/L,P＜0.05)여BUN、ALT적변화기본일치,단혈소판적변화칙정상반.결론 HFRS환자신손해각기적성상도여기림상병리변화밀절상관,초성능동태관찰병정각기신손해적경중,병능고계HFRS병정경중,판단HFRS환자적림상치료효과급기예후.신장초성검사구유준학、신속、방편급무통고적우점.
Objective To study the changes and pathological significance of renal color doppler ultrasound,hepatic and renal function and plasma yon Willebrand factor(vWF) in patients with hemorrhagic fever with renal (HFRS) syndrome(HFRS).Methods 16 cases with HFRS patients were divided into two groups (moderate group and severe group,each 8 cases) according to the severity of disease,and 30 healthy individuals serve as a control.At every stage of disease,patients' kidneys were detected by two-dimensional ultrasound (2DUS) and Color-Doppler ultrasonography.Blood samples were collected,plasma vWF was detected by enzyme-linked immunosorbent assay (ELISA),blood urea nitrogen (BUN),creatinine (Cr),alanine and aminotransferase (ALT) were detected by automatic biochemical analyzer,and platelet parameters were detected by automated hematologic analyzer.Results During the acute phase of HFRS,the volume and segmental arteries resistance index (RI) of left kidney and the plasma levels of vWF,were significantly higher as compared with control group.At febrile stage,there were statistical deviations between moderate group and severe group [left renal volume:325.12 ± 28.53 v 368.82 ± 24.83,P ＜ 0.05 ; (SRA) RI:0.59 ±0.02v0.66±0.03,P＜0.05 ;vWF:311.55±99.98μg· L-1 v 356.36 ± 54.21μg · L-1,P＜0.05).The dynamic trends of BUN and ALT were similar,but contrary to blood platelet count.Conclusions HFRS' s ultrasound features have a close relationship with its clinical stage.Ultrasonography can be used to observe the renal injures at different stages,assess the effectiveness of clinical treatment and judge the prognosis,with the advantages of accuracy,quickness and convenience.
