CAJ | 학술논문

目的分析病毒性肝炎患者干眼症患病特点.方法收集2011年1月至2013年12月就诊于北京佑安医院眼科的病毒性肝炎患者292例(其中乙型肝炎253例、丙型肝炎39例),进行干眼症的相关检查以及肝功能检查,包括询问病史、裂隙灯检查、角膜荧光素染色、泪膜破裂时间(BUT)检查和泪液分泌试验(schirmer test),并检测患者丙氨酸氨基转移酶、总胆红素、白蛋白等.结果 292例病毒性肝炎患者中,干眼症208例,非干眼症患者84例.其中男性169例,干眼症者119例;女性123例,干眼症者89例.干眼症组与非干眼症组年龄分别为47±12岁、44±13岁;丙氨酸氨基转移酶中位数值分别为37.61U·l-1、27.30 U· l-1;总胆红素中位数值分别为25.26umol·l-1、15.35umol·l-1;白蛋白分别为42.72 ±6.10g·l-1、44.04 ±4.21g·l-1.其中年龄、总胆红素以及白蛋白三项,在干眼症与非干眼症患者间差异有统计学意义.在所有208例干眼症患者中乙肝177例,占85.10％;丙肝31例,占14.90％,乙型和丙型病毒性肝炎患者间干眼症患病情况无统计学差异.乙型和丙型病毒性肝炎患者Schirmer Ⅰ试验以及BUT检查结果无统计学差异.年龄及总胆红素与病毒性肝炎患者干眼症有相关性.结论病毒性肝炎患者干眼症有其自身特点,其干眼症发生率高,且与性别无相关性,与年龄相关.乙型肝炎及丙型肝炎干眼症发生情况无统计学差异.
목적 분석병독성간염환자간안증환병특점.방법 수집2011년1월지2013년12월취진우북경우안의원안과적병독성간염환자292례(기중을형간염253례、병형간염39례),진행간안증적상관검사이급간공능검사,포괄순문병사、렬극등검사、각막형광소염색、루막파렬시간(BUT)검사화루액분비시험(schirmer test),병검측환자병안산안기전이매、총담홍소、백단백등.결과 292례병독성간염환자중,간안증208례,비간안증환자84례.기중남성169례,간안증자119례;녀성123례,간안증자89례.간안증조여비간안증조년령분별위47±12세、44±13세;병안산안기전이매중위수치분별위37.61U·l-1、27.30 U· l-1;총담홍소중위수치분별위25.26umol·l-1、15.35umol·l-1;백단백분별위42.72 ±6.10g·l-1、44.04 ±4.21g·l-1.기중년령、총담홍소이급백단백삼항,재간안증여비간안증환자간차이유통계학의의.재소유208례간안증환자중을간177례,점85.10％;병간31례,점14.90％,을형화병형병독성간염환자간간안증환병정황무통계학차이.을형화병형병독성간염환자Schirmer Ⅰ시험이급BUT검사결과무통계학차이.년령급총담홍소여병독성간염환자간안증유상관성.결론 병독성간염환자간안증유기자신특점,기간안증발생솔고,차여성별무상관성,여년령상관.을형간염급병형간염간안증발생정황무통계학차이.
Objective To analyze the characteristics of dry eye syndrome in viral hepatitis patients.Methods Two hundred and ninety-two patients with viral hepatitis,including 253 cases of hepatitis B,39 cases of hepatitis C visited our department of ophthalmology and were enrolled in this study.All patients received eye examination and liver function tests,including medical history,slit lamp examination,corneal fluorescein staining,tear film break-up time (BUT) and schirmer test,alanine aminotransferase (ALT),total bilirubin (TBil),albumin (ALB).Results In the 292 cases of viral hepatitis,there were 208 dry eye cases and 84 non-dry eye cases.In 169 male cases,119 cases had dry eyes; in 123 femalecases,89 cases were with dry eyes.In the dry eyes group and non-dry eyes group,the ages were 47 ± 12 and 44 ± 13 years old,respectively.The median values of alanine aminotransferase was 37.61U l-1 and 27.3U l-1; the median values of total bilirubin were 25.26umol· l-1 and 15.35umolⅠ·l-1 and albumin values were 41.81 ±6.49g l-1,43.56 ± 4.59g l-1.There were statistics difference in age,total bilirubin and albumin values between dry eye and non-dry eye groups.In the 208 hepatitis B patients,85.10％ showed dry eye (177 cases) ; 14.90％ of the 31 hepatitis C cases had dry eyes.There was no significant difference between the prevalence of dry eye syndrome in hepatitis B and hepatitis C viral hepatitis patients.There was no significant difference in Schirmer I test and BUT between different types of viral hepatitis.Ages and total bilirubin values were the correlation factors in viral hepatitis and dry eye.Conclusions Viral hepatitis patients with dry eye syndrome has its own characteristics,including high incidence of dry eyes in patients with viral hepatitis.Dry eye has no correlation with gender.There was no significant difference of dry eye syndrome in hepatitis B and hepatitis C patients.Age and total bilirubin values correlated with viral hepatitis and dry eye.