国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2014年
2期
198-201
,共4页
钙结合蛋白%粪便%早产儿%肠道喂养%喂养不耐受
鈣結閤蛋白%糞便%早產兒%腸道餵養%餵養不耐受
개결합단백%분편%조산인%장도위양%위양불내수
Calcium-binding proteins%Feces%Infant,Premature%Enteral nutrition%Feeding intolerance
目的 动态测定早产儿生后2周内粪便钙卫蛋白(fecal calprotectin,FC)水平,分析影响FC分泌的临床因素,探讨其在评价早产儿胃肠功能的价值.方法 2012年5～9月中国医科大学附属盛京医院新生儿科收治的胎龄≤32周或出生体重≤l 200g的早产儿47例,根据生后第7d的喂养情况分成喂养耐受组29例及喂养不耐受组18例.收集生后第1次胎便、第7d及第14 d最后一次粪便(以下依次简称为FC1、FC2和FC3)50～100 mg.用酶联免疫吸附法(ELASA)测定FC水平.结果 47例早产儿FC3水平明显高于FC1和FC2水平(P＜0.05);FC1与FC2水平差异无统计学意义(P＞0.05).母亲分娩前有产前感染的早产儿FC1水平明显高于无产前感染者(P＜0.05).FC2水平与生后抗生素使用时间(d)呈显著负相关(r =-0.325,P＜0.05).喂养不耐受组FC2水平明显低于喂养耐受组(P＜0.05).喂养耐受组FC2、喂养不耐受组FC3水平分别与第7d和第14 d的肠道喂养量呈显著正相关(r =0.433,0.479,P＜0.05).结论 产前感染及生后肠道喂养可促进早产儿胃肠道分泌FC,生后早期FC水平可反映早产儿早期胃肠道喂养情况,可作为评价早产儿生后早期消化道功能的无创性生物学指标.
目的 動態測定早產兒生後2週內糞便鈣衛蛋白(fecal calprotectin,FC)水平,分析影響FC分泌的臨床因素,探討其在評價早產兒胃腸功能的價值.方法 2012年5～9月中國醫科大學附屬盛京醫院新生兒科收治的胎齡≤32週或齣生體重≤l 200g的早產兒47例,根據生後第7d的餵養情況分成餵養耐受組29例及餵養不耐受組18例.收集生後第1次胎便、第7d及第14 d最後一次糞便(以下依次簡稱為FC1、FC2和FC3)50～100 mg.用酶聯免疫吸附法(ELASA)測定FC水平.結果 47例早產兒FC3水平明顯高于FC1和FC2水平(P＜0.05);FC1與FC2水平差異無統計學意義(P＞0.05).母親分娩前有產前感染的早產兒FC1水平明顯高于無產前感染者(P＜0.05).FC2水平與生後抗生素使用時間(d)呈顯著負相關(r =-0.325,P＜0.05).餵養不耐受組FC2水平明顯低于餵養耐受組(P＜0.05).餵養耐受組FC2、餵養不耐受組FC3水平分彆與第7d和第14 d的腸道餵養量呈顯著正相關(r =0.433,0.479,P＜0.05).結論 產前感染及生後腸道餵養可促進早產兒胃腸道分泌FC,生後早期FC水平可反映早產兒早期胃腸道餵養情況,可作為評價早產兒生後早期消化道功能的無創性生物學指標.
목적 동태측정조산인생후2주내분편개위단백(fecal calprotectin,FC)수평,분석영향FC분비적림상인소,탐토기재평개조산인위장공능적개치.방법 2012년5～9월중국의과대학부속성경의원신생인과수치적태령≤32주혹출생체중≤l 200g적조산인47례,근거생후제7d적위양정황분성위양내수조29례급위양불내수조18례.수집생후제1차태편、제7d급제14 d최후일차분편(이하의차간칭위FC1、FC2화FC3)50～100 mg.용매련면역흡부법(ELASA)측정FC수평.결과 47례조산인FC3수평명현고우FC1화FC2수평(P＜0.05);FC1여FC2수평차이무통계학의의(P＞0.05).모친분면전유산전감염적조산인FC1수평명현고우무산전감염자(P＜0.05).FC2수평여생후항생소사용시간(d)정현저부상관(r =-0.325,P＜0.05).위양불내수조FC2수평명현저우위양내수조(P＜0.05).위양내수조FC2、위양불내수조FC3수평분별여제7d화제14 d적장도위양량정현저정상관(r =0.433,0.479,P＜0.05).결론 산전감염급생후장도위양가촉진조산인위장도분비FC,생후조기FC수평가반영조산인조기위장도위양정황,가작위평개조산인생후조기소화도공능적무창성생물학지표.
Objective To determine the time course of fecal calprotectin (FC) excretion in preterm infants in the first two weeks of life and to identify influencing factors of FC levels.To explore whether FC may be an useful marker for the identification of gastrointestinal conditions in preterm infants.Methods FC concentration was measured using ELISA in 141 samples (50-100 mg)obtained from 47 preterm infants(gestational age less than 32 weeks or birth weight less than 1 200 grams)at birth,on day 7 and on day 14(The following was called FC1,FC2 and FC3 level for short).Results FC3 level was significantly higher than FC1 and FC2 levels (P ＜0.05),there were no significant differences between FC1 and FC2 levels in the 47 preterm infants(P ＞ 0.05).The FC1 level in infants whose mothers had antenatal infection was significantly higher(P ＜ 0.05).The FC2 level was negatively correlated with the antibiotic courses(r =-0.325,P ＜ 0.05).The FC2 level in infants with feeding intolerance was significantly lower than that in infants with feeding tolerance(P ＜ 0.05).The FC2 level in infants with feeding tolerance and the FC3 level in infants with feeding intolerance were positively correlated with the volume of enteral feeds,respectively (r =0.433,0.479,P ＜ 0.05).Contusion Antenatal infection and postnatal enteral feeds may lead to an increase in the excretion of FC in preterm infants.FC level was associated with enteral feeding and may be a useful marker for evaluation of gastrointestinal function in preterm infants.
