CAJ | 학술논문

目的研究对甲基桂皮丹酚酯的抗辐射活性.方法以6～8周龄的ICR小鼠作为研究对象,经137Csγ射线一次性全身照射后,以30 d存活率、血液生化指标、脏器指数及肺和肝的超氧化物歧化酶(SOD)、丙二醛为指标,考察低、中、高3个剂量组的对甲基桂皮丹酚酯的抗辐射损伤效应.结果对甲基桂皮丹酚酯可以提高经8.5 Gy 137Cs γ射线一次性全身照射损伤ICR小鼠的30 d存活率,对小鼠经6.5 Gy 137Cs γ射线一次性全身照射损伤生理指标影响的检测结果显示,对甲基桂皮丹酚酯在不同程度上提高了血小板和DNA含量、胸腺指数和脾脏指数；且SOD水平随着对甲基桂皮丹酚酯剂量的增加而增加,而丙二醛水平则有所降低,尤其是高剂量组的效果较显著.结论对甲基桂皮丹酚酯可能具有抗辐射损伤作用.
목적 연구대갑기계피단분지적항복사활성.방법 이6～8주령적ICR소서작위연구대상,경137Csγ사선일차성전신조사후,이30 d존활솔、혈액생화지표、장기지수급폐화간적초양화물기화매(SOD)、병이철위지표,고찰저、중、고3개제량조적대갑기계피단분지적항복사손상효응.결과 대갑기계피단분지가이제고경8.5 Gy 137Cs γ사선일차성전신조사손상ICR소서적30 d존활솔,대소서경6.5 Gy 137Cs γ사선일차성전신조사손상생리지표영향적검측결과현시,대갑기계피단분지재불동정도상제고료혈소판화DNA함량、흉선지수화비장지수；차SOD수평수착대갑기계피단분지제량적증가이증가,이병이철수평칙유소강저,우기시고제량조적효과교현저.결론 대갑기계피단분지가능구유항복사손상작용.
Objective To study the radiaition protective effect of P-methyl cinnamic paeonol esters on irradiated mice.Methods ICR mice of age 6-8 weeks were selected as investigated subjects,then the mice whole body were irradiated with 6.5 Gy or 8.5 Gy137Cs γ-ray.The 30-day survival rates,organ indexes,superoxide dismutase (SOD)and malondialdehyde levels in lung and liver were observed to evaluate the radiation protective effect of P-methyl cinnamic paeonol esters in high,medium,low dose groups.Results P-methyl cinnamic paeonol esters increased the 30-day survival rates of 8.5 Gy whole body irradiated mice.And after 6.5 Gy whole body irradiation,P-methyl cinnamic paeonol esters could enhance the platelet counts,DNA levels and thymus,spleen index.Meanwhile,SOD levels were increased with the increasing dose of P-methyl cinnamic paeonol esters,while malondialdehyde levels were decreased,especially in the high dose group.Conclusion Pmethyl cinnamic paeonol esters may play an important role in radiation resistance.