CAJ | 학술논문

有关癌干细胞及其生物学特性研究信息的不断积累,推动了放射肿瘤生物学的发展.近年来的研究发现,癌于细胞和静止期癌细胞可能是导致肿瘤放射抗性增加和肿瘤放射治疗后复发的主要细胞学基础,有关这两种癌细胞亚群的放射敏感性及其机制的研究进展迅速,为提高肿瘤对放射治疗敏感性的措施研究提供了新的学术思路.该文将就癌细胞亚群的放射分子生物学特性,分析讨论肿瘤放射抗性的细胞学基础和相关分子机制.
유관암간세포급기생물학특성연구신식적불단적루,추동료방사종류생물학적발전.근년래적연구발현,암우세포화정지기암세포가능시도치종류방사항성증가화종류방사치료후복발적주요세포학기출,유관저량충암세포아군적방사민감성급기궤제적연구진전신속,위제고종류대방사치료민감성적조시연구제공료신적학술사로.해문장취암세포아군적방사분자생물학특성,분석토론종류방사항성적세포학기출화상관분자궤제.
The gradually accumulated information and knowledge regarding cancer stem cell or stem-like cancer cell greatly potentiated the research progression of radiation oncology and biology.In recent years,a series studies have uncovered that the cancer stem cell and cancer quiescent cell could be the major cells origin attributed to the radioresistance and recurrence of tumors in the course of radiotherapy.A rapid research progression has already been achieved respecting the radiosensitivity and related mechanisms of these two subsets of cancer cells,and which provides an idea strategy for development of the measures targeting tumor radioresistance.This paper reviewed and discussed the cellular basis and molecular mechanism of the tumor radioresistance from the aspects of cancer cells subsets and the radiobiological characteristics.