国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2013年
5期
269-271
,共3页
甲状腺肿瘤%甲状腺球蛋白%碘放射性同位素
甲狀腺腫瘤%甲狀腺毬蛋白%碘放射性同位素
갑상선종류%갑상선구단백%전방사성동위소
Thyroid neoplasms%Thyroglobulin%Iodine radioisotopes
目的 评价131I全身显像联合血清甲状腺球蛋白(Tg)测定在分化型甲状腺癌(DTC)131I治疗随访中的临床应用价值.方法 153例经手术病理确诊为DTC的患者,均在术后接受了1次以上的131I治疗,每次剂量为1.85～9.25 GBq,131I治疗前测定血清Tg,治疗5d后进行131I全身显像.结果 153例行131I治疗的DTC患者共行血清Tg和131I全身显像检查各为262次,其中55.6％(85/153)的患者的血清Tg水平与131I全身显像均异常,13.7％(21/153)的患者两者均为正常,30.7％(47/153)的患者两者结果不一致,不一致的47例患者经其他影像学检查证实19例131I全身显像异常的患者中有13例异常,28例血清Tg异常的患者中有25例异常.血清Tg诊断DTC转移的灵敏度和特异度分别为89％(110/123)和90％ (27/30),而131I全身显像的灵敏度和特异度分别为79.6％(98/123)和80％(24/30).结论 DTC手术及131I治疗后,常规进行血清Tg测定和131I全身显像检查,对术后判定复发转移灶及制定最佳131I诊疗计划、评价131I疗效具有重要的临床应用价值.
目的 評價131I全身顯像聯閤血清甲狀腺毬蛋白(Tg)測定在分化型甲狀腺癌(DTC)131I治療隨訪中的臨床應用價值.方法 153例經手術病理確診為DTC的患者,均在術後接受瞭1次以上的131I治療,每次劑量為1.85～9.25 GBq,131I治療前測定血清Tg,治療5d後進行131I全身顯像.結果 153例行131I治療的DTC患者共行血清Tg和131I全身顯像檢查各為262次,其中55.6％(85/153)的患者的血清Tg水平與131I全身顯像均異常,13.7％(21/153)的患者兩者均為正常,30.7％(47/153)的患者兩者結果不一緻,不一緻的47例患者經其他影像學檢查證實19例131I全身顯像異常的患者中有13例異常,28例血清Tg異常的患者中有25例異常.血清Tg診斷DTC轉移的靈敏度和特異度分彆為89％(110/123)和90％ (27/30),而131I全身顯像的靈敏度和特異度分彆為79.6％(98/123)和80％(24/30).結論 DTC手術及131I治療後,常規進行血清Tg測定和131I全身顯像檢查,對術後判定複髮轉移竈及製定最佳131I診療計劃、評價131I療效具有重要的臨床應用價值.
목적 평개131I전신현상연합혈청갑상선구단백(Tg)측정재분화형갑상선암(DTC)131I치료수방중적림상응용개치.방법 153례경수술병리학진위DTC적환자,균재술후접수료1차이상적131I치료,매차제량위1.85～9.25 GBq,131I치료전측정혈청Tg,치료5d후진행131I전신현상.결과 153례행131I치료적DTC환자공행혈청Tg화131I전신현상검사각위262차,기중55.6％(85/153)적환자적혈청Tg수평여131I전신현상균이상,13.7％(21/153)적환자량자균위정상,30.7％(47/153)적환자량자결과불일치,불일치적47례환자경기타영상학검사증실19례131I전신현상이상적환자중유13례이상,28례혈청Tg이상적환자중유25례이상.혈청Tg진단DTC전이적령민도화특이도분별위89％(110/123)화90％ (27/30),이131I전신현상적령민도화특이도분별위79.6％(98/123)화80％(24/30).결론 DTC수술급131I치료후,상규진행혈청Tg측정화131I전신현상검사,대술후판정복발전이조급제정최가131I진료계화、평개131I료효구유중요적림상응용개치.
Objective To evaluate the clinical value of 131I whole body scans with that of serum thyroglobulin (Tg)determination for the follow-up of differentiated thyroid carcinoma(DTC)receiving postoperative 131I therapy.Methods There were 153 patients with differentiated thyroid cancer receiving postoperative 131I therapy for more than one time at the dose of 1.85-9.25 GBq.Serum Tg levels were measured before 131I treatment and 131I whole body scans were performed 5 days after treatment.Results Among the 153 patients who underwent 131I therapy,serum Tg levels and 131I-whole body scans were both abnormal in 85 patients (55.6％).Both examinations were negative in 21 patients (13.7％).In the 19 patients with abnormal 131I whole body scans only,image study with means of 18F-FDG,SPECT,CT,ultrasonic or whole body bone scan revealed lesions in 13 patients; while in the 28 patients with abnormal Tg levels only,image study with the above means revealed lesions in 25 patients.The sensitivity of Tg positiveness and 131I whole body scans positiveness were 89％ (110/123) and 79.6％ (98/123) respectively,and the specificity were 90％ (27/30)and 80％ (24/30)respectively.Conclusions Routine serum Tg measurement and 131I whole body scans in patients with DTC with 131I radiotherapy after thyroidectomy is essential.It is of greatly clinical value in early detecting metastases,optimizing the 131I treatment protocol and evaluating the curative effect.
