国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
7期
508-512
,共5页
哮喘%呼出气一氧化氮%诊断%受试者工作特征曲线%肺功能测试
哮喘%呼齣氣一氧化氮%診斷%受試者工作特徵麯線%肺功能測試
효천%호출기일양화담%진단%수시자공작특정곡선%폐공능측시
Asthma%Fractional exhaled nitric oxide%Diagnosis%Receiver operating characteristic curves%Pulmonary function test
目的 评价呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)检测诊断哮喘的准确性及其最佳界值.方法 使用FeNO测试仪(NIOX MINO Aerocrine AB瑞典)对109例疑诊哮喘患者进行FeNO浓度测定,以哮喘的常规诊断方法为参照.不同的FeNO界值对应不同的敏感度和特异度,绘制ROC曲线,评价FeNO诊断哮喘的准确性并得出最佳界值.结果 109例患者中,47例最终被诊断为哮喘,62例非哮喘患者.哮喘组FeNO中位数(四分位数间距)明显高于非哮喘组:70 ppb(87 ppb)比16 ppb(21 ppb),P＜0.001.ROC曲线下面积为0.808(95％置信区间:0.719～0.896),FeNO诊断哮喘的最佳界值为41 ppb,以41 ppb为标准诊断哮喘的敏感度为68.1％,特异度为83.9％,阳性预测值为76.2％,阴性预测值为77.6％,准确度为77.1％.结论 FeNO诊断哮喘的敏感性和特异性是可接受的,可以被用作哮喘诊断的辅助工具.
目的 評價呼齣氣一氧化氮(fractional exhaled nitric oxide,FeNO)檢測診斷哮喘的準確性及其最佳界值.方法 使用FeNO測試儀(NIOX MINO Aerocrine AB瑞典)對109例疑診哮喘患者進行FeNO濃度測定,以哮喘的常規診斷方法為參照.不同的FeNO界值對應不同的敏感度和特異度,繪製ROC麯線,評價FeNO診斷哮喘的準確性併得齣最佳界值.結果 109例患者中,47例最終被診斷為哮喘,62例非哮喘患者.哮喘組FeNO中位數(四分位數間距)明顯高于非哮喘組:70 ppb(87 ppb)比16 ppb(21 ppb),P＜0.001.ROC麯線下麵積為0.808(95％置信區間:0.719～0.896),FeNO診斷哮喘的最佳界值為41 ppb,以41 ppb為標準診斷哮喘的敏感度為68.1％,特異度為83.9％,暘性預測值為76.2％,陰性預測值為77.6％,準確度為77.1％.結論 FeNO診斷哮喘的敏感性和特異性是可接受的,可以被用作哮喘診斷的輔助工具.
목적 평개호출기일양화담(fractional exhaled nitric oxide,FeNO)검측진단효천적준학성급기최가계치.방법 사용FeNO측시의(NIOX MINO Aerocrine AB서전)대109례의진효천환자진행FeNO농도측정,이효천적상규진단방법위삼조.불동적FeNO계치대응불동적민감도화특이도,회제ROC곡선,평개FeNO진단효천적준학성병득출최가계치.결과 109례환자중,47례최종피진단위효천,62례비효천환자.효천조FeNO중위수(사분위수간거)명현고우비효천조:70 ppb(87 ppb)비16 ppb(21 ppb),P＜0.001.ROC곡선하면적위0.808(95％치신구간:0.719～0.896),FeNO진단효천적최가계치위41 ppb,이41 ppb위표준진단효천적민감도위68.1％,특이도위83.9％,양성예측치위76.2％,음성예측치위77.6％,준학도위77.1％.결론 FeNO진단효천적민감성화특이성시가접수적,가이피용작효천진단적보조공구.
Objective To assess the accuracy of exhaled nitric oxide for the diagnosis of bronchial asthma (asthma) and to determine the optimal cutoff value.Methods 109 patients received a FeNO test by nitric oxide analyzer (NIOX MINO,Aerocrine AB,Solna,Sweden),referenced the conventional diagnostic methods of asthma.Different FeNO measurements corresponds to different degrees of sensitivity and specificity.The accuracy of FeNO was assessed and the optimal cutoff value of FeNO was determined by the means of the receiver operating characteristic (ROC) curves.Results A total of 109 patients were enrolled,in which 47 cases were diagnosed as asthma.and in which 62 cases were diagnosed as non asthmatics.The asthma group FeNO median (interquartile range) was significantly higher than the non-asthmatic group:70 ppb (87 ppb) vs 16 ppb (21 ppb),P＜0.001.The area under the ROC curve was 0.808 (95％ CI:0.719 to 0.896,P ＜0.001).The optimal FeNO cutoff value was 41 ppb with a sensitivity of 68.1％,a specificity of 83.9％,a positive predictive value of 76.2％,a negative predictive value of 77.6％ and an accuracy of 77.1％.Conclusions FeNO can be used as an additional diagnostic tool for the screening of patients with a suspected diagnosis of asthma.
