CAJ | 학술논문

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)在全球范围内患病率极高,急性加重是其就诊、住院治疗及医疗开支的主要原因.目前的研究对细菌感染在急性加重患者中的作用意见不一,如能为抗菌治疗在慢性阻塞性肺疾病急性加重(AECOPD)提供早期、快速的客观依据将极有价值.髓系细胞触发受体1及血清淀粉样蛋白A是新近发现的标志物,两者在感染与非感染性炎症、细菌感染与非细菌感染性炎症中表达的不同,将为AECOPD疾病严重程度的评估、细菌感染的鉴别提供重要依据.
만성조새성폐질병(chronic obstructive pulmonary disease,COPD)재전구범위내환병솔겁고,급성가중시기취진、주원치료급의료개지적주요원인.목전적연구대세균감염재급성가중환자중적작용의견불일,여능위항균치료재만성조새성폐질병급성가중(AECOPD)제공조기、쾌속적객관의거장겁유개치.수계세포촉발수체1급혈청정분양단백A시신근발현적표지물,량자재감염여비감염성염증、세균감염여비세균감염성염증중표체적불동,장위AECOPD질병엄중정도적평고、세균감염적감별제공중요의거.
Due to high prevalence rate of chronic obstructive pulmonary disease (COPD)worldwide,acute exacerbation has been the major cause for out-patient clinics,hospitalization and increasing medical costs.The role that bacterial infection plays in acute exacerbation remains currently controversial,thus premature and prompt objective proofs for antimicrobial therapy may be of remarkable significance.Recently,triggering receptor expressed on myeloid cell-1 and serum amyloid A were revealed as biomarkers in acute exacerbation of COPD,and were of significance in assessing disease severity and offering proofs for bacterial infection based on their distinction in biological features in terms of infectious or non-infectious inflammation,bacterial infection and non-bacterial infectious inflammation.