国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
14期
1091-1095
,共5页
YKL-40%肺部疾病%炎症%纤维化
YKL-40%肺部疾病%炎癥%纖維化
YKL-40%폐부질병%염증%섬유화
YKL-40%Pulmonary disease%Inflammation%Fibrosis
几丁质酶样蛋白-40(YKL-40)属于18糖基水解酶家族成员之一,由一些恶性细胞和非恶性细胞所分泌,几乎涉足人类的所有疾病,如肿瘤、感染、自身免疫以及代谢性疾病等,具有促进炎症、纤维化、组织重塑、肿瘤细胞生长以及拮抗凋亡等生物功能.同样,也参与了许多肺部疾病的病理生理过程,如支气管哮喘、慢性阻塞性肺疾病、特发性肺间质纤维化、结节病、肺癌等.本文就YKL-40参与的肺部疾病进行综述.
幾丁質酶樣蛋白-40(YKL-40)屬于18糖基水解酶傢族成員之一,由一些噁性細胞和非噁性細胞所分泌,幾乎涉足人類的所有疾病,如腫瘤、感染、自身免疫以及代謝性疾病等,具有促進炎癥、纖維化、組織重塑、腫瘤細胞生長以及拮抗凋亡等生物功能.同樣,也參與瞭許多肺部疾病的病理生理過程,如支氣管哮喘、慢性阻塞性肺疾病、特髮性肺間質纖維化、結節病、肺癌等.本文就YKL-40參與的肺部疾病進行綜述.
궤정질매양단백-40(YKL-40)속우18당기수해매가족성원지일,유일사악성세포화비악성세포소분비,궤호섭족인류적소유질병,여종류、감염、자신면역이급대사성질병등,구유촉진염증、섬유화、조직중소、종류세포생장이급길항조망등생물공능.동양,야삼여료허다폐부질병적병리생리과정,여지기관효천、만성조새성폐질병、특발성폐간질섬유화、결절병、폐암등.본문취YKL-40삼여적폐부질병진행종술.
YKL-40 belongs to 18 glycosyl hydrolase family members,is secreted by some malignant and non-malignant cells,and involved in almost all human diseases,such as tumor,infection,autoimmune and metabolic diseases,etc.It has been proved to promote inflammation,fibrosis,tissue remodeling,cell growth,and inhibit apoptosis.In addition,YKL-40 is also involved in the pathophysiological process of many lung diseases,such as bronchial asthma,chronic obstructive pulmonary disease,idiopathic pulmonary fibrosis,lung sarcoidosis,etc.This article reviews the basic biological features of YKL-40 and its involvement in different lung diseases.
