CAJ | 학술논문

慢性阻塞性肺疾病(COPD)是一种以持续存在气流受限为特征,以气道、肺实质及肺血管的慢性炎症为核心的多因素构成的慢性疾病.二肽基肽酶Ⅳ分布于人体多种组织中,参与了许多不同的生理过程,其中血清中可溶性二肽基肽酶Ⅳ(sDPPⅣ)水平改变可能与多种疾病有关.有研究显示,COPD患者血清sDPPⅣ浓度明显降低,且与年龄、吸烟因素无关,可能对COPD有早期血清学辅助诊断意义.
만성조새성폐질병(COPD)시일충이지속존재기류수한위특정,이기도、폐실질급폐혈관적만성염증위핵심적다인소구성적만성질병.이태기태매Ⅳ분포우인체다충조직중,삼여료허다불동적생리과정,기중혈청중가용성이태기태매Ⅳ(sDPPⅣ)수평개변가능여다충질병유관.유연구현시,COPD환자혈청sDPPⅣ농도명현강저,차여년령、흡연인소무관,가능대COPD유조기혈청학보조진단의의.
Chronic obstructive pulmonary disease(COPD) is a type of chronic disease characterized by progressive airflow limitation,which is composed by core factors,such as airway,lung parenchyma and pulmonary vascular chronic inflammation.Dipeptidyl peptidase Ⅳ is distributed in various body tissues,participating in various physiological procedures.Charges in the level of serum soluble dipeptidyl peptidase Ⅳ (sDPPⅣ) may be related to many diseases.It has been shown that sDPPIV concentration in serum is not related with age or smoking,thus it may be of significance in early serological diagnosis of COPD.